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A B S T R A C TThis paper focuses on nanofiltration (NF) process mainly in the retention of colored effluents chemicals and dyes as they are rejected from textile plants. The purpose of this work is to study the effect of initial dye concentration, pH, salt presence, conversion rate, and transmembrane pressure (PTM) on Basic Green 4 and Basic Yellow 2 retention by NF. Tangential filtration mode through a composite membrane NF270 type Dow FILMTEC was used in the experiments. Experimental designs such as full factorial design and Box-Behnken matrix were used. Tests have shown that the pH, the conversion rate, and salt concentration have a negative influence on Basic Green 4 and Basic Yellow 2 retention. By comparison, the PTM and initial dye concentration have a positive effect on the retention of these dyes. Finally, the retention rate for Basic Yellow 2 and Basic Green 4 was higher than 90% in our study.