Background: Psoriasis is a chronic inflammatory disease with frequent recurrence. The associated complications cause disturbance in patients' quality of life. In addition to treatment procedures, use of self-care behaviors can be considered a cost-effective and applicable method in improving the patients' symptoms. Therefore, the present study aimed to investigate the effectiveness of a self-care program in promoting self-care behaviors of patients with psoriasis. Objectives: The present study aimed to investigate the effectiveness of a self-care program in promoting self-care behaviors among patients with psoriasis. Methods: This quasi experimental, before-after study was carried out on 32 patients. The educational program was implemented face-to-face and in groups (in areas such as medicine, bathing, and clothing). The samples were examined once every 2 weeks for 3 months. Two questionnaires and 1 self-report checklist with a correlation coefficient of 92.5% were used in this study. The validity of the questionnaires was determined using content validity. Data were analyzed using repeated measures ANOVA in SPSS. Results: The patients' demographics were as follows: mean age, 42.37%; males, 16 (55.2%) and females, 13 (44.8%); married, 21 (72.4%), single, 6 (20.7%), and widowed, 2 (6.9%); secondary school education, 13 (44.8%); average disease period, 9.03%; most self-employed and housewives (9, 31%); history of disease, 7 (24.1%); and physician-diagnosed disease, 29 (100%). The results showed that the mean medication adherence rate increased from 7% to 9.72% after the intervention, and comparison of self-care behaviors before and after the intervention showed that the frequency of most behaviors significantly increased. Conclusions:The results showed that training could improve self-care behaviors. Use of simple, low-cost, and available programs for self-care behaviors is effective in reducing the patients' symptoms and improving their conditions.