An efficient synthetic procedure for the synthesis of functionalized tetrahydrospiro[indoline‐3,2′‐quinoline] derivatives was successfully developed and involves the four‐component reaction of arylamines, dimethyl acetylenedicarboxylate, isatins, and a cyclohexane‐1,3‐dione in acetic acid. The advantages of this reaction include the use of common starting materials and mild reaction conditions and it is operationally simple.

Spiro[indoline-3,3′-pyrrolizines] and spiro[indoline-3,7′-pyrrolo[1,2-a]azepines] can be selectively produced from three-component reaction of α-amino acids, isatins and but-2-ynedioates.

A practical procedure for the preparation of fused 1,4-dihydropyridines was developed through the domino four-component reactions of arylamines, acetylenedicarboxylate, aro-

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SummaryIn the presence of p-toluenesulfonic acid as catalyst the domino reaction of arylamines, methyl propiolates and aromatic aldehydes in ethanol proceeded smoothly to give polysubstituted 1,2,3,4-tetrahydroquinolines in moderate yields. The reaction is believed to involve the Povarov reaction of in situ generated β-enamino ester with the in situ formed aromatic imine.