Background To investigate the safety and effectiveness of tubal inflammatory drugs in patients with incomplete tubal obstruction of at least 1 side after four-dimensional hysterosalpingo-contrast-sonography (4D-HyCoSy) examination. Methods 215 cases of tubal insufficiency were diagnosed by ultrasonography from February 2019 to November 2020.According to retrospective analysis,the patients in this study were divided into experimental and control groups; the experimental group was treated with a push of salpingitis drugs, and the control group received blank control. Basic information, degree of pain, postoperative complications, and pregnancy rate were then compared between the 2 groups. Result(s) : Compared with the control group, there was no significant difference in the basic information; preoperative, intraoperative, or postoperative pain; or in postoperative complications (P > 0.05). The cumulative pregnancy rate of the experimental group (28.0%) was statistically different from that of the control group (15.3%) (P < 0.05). Conclusion(s): We observed that for infertile patients with incomplete obstruction of at least one fallopian tube as diagnosed by contrast-enhanced ultrasonography, salpingitis-treatment drugs effectively improved the pregnancy rate postoperatively, with high effectiveness and safety. This regimen is thus worthy of further investigation and promotion in the future.