Synopsis Rosmarinic acid (RA) has a number of interesting biological activities, e.g. anti‐viral, anti‐bacterial, anti‐inflammatory and antioxidant. The antioxidant activity of RA is stronger than that of vitamin E. Despite its strong antioxidant activity, it was limited to use in cosmetics because of the low water solubility, discolouration and chemical instability. The purpose of this study was to prepare RA‐loaded polycaprolactone (PCL) microspheres using emulsion solvent evaporation method and characterize them with different surfactants used in the formation process. Finally, long‐term stability of RA was evaluated in the cosmetic formulation. As a result, PCL microspheres were found to be spherical in shape, with zwitterionic surfactant‐PCL particles being the smallest size distribution and highest entrapment efficiency of RA. Emulsions containing RA‐loaded PCL microspheres showed a better long‐term stability of the RA compared with those containing only RA. These results suggest that RA may be stably and efficiently encapsulated into polycaprolactone microspheres.

The water-soluble fullerenes [C 60 , C 70 ] are prepared with fullerenes [C 60 , C 70 ] and a mixture of oxidants (v/v) at the ratio of 3:1 under ultrasonic condition at room temperature. The MALDI-TOF MS confirmed that the water-soluble compounds were C 60 and C 70 . The antioxidant effect of water-soluble fullerenes [C 60 , C 70 ] in the PC 12 cells (Rat pheochromocytoma) line following exposure to hydrogen peroxide (H 2 O 2 ) was investigated.