We estimate the effective reproduction number for 2019-nCoV based on the daily reported cases from China CDC. The results indicate that 2019-nCoV has a higher effective reproduction number than SARS with a comparable fatality rate.

Estimating the key epidemiological features of the novel coronavirus (2019-nCoV) epidemic proves to be challenging, given incompleteness and delays in early data reporting, in particular, the severe under-reporting bias in the epicenter, Wuhan, Hubei Province, China. As a result, the current literature reports widely varying estimates. We developed an alternative geostratified debiasing estimation framework by incorporating human mobility with case reporting data in three stratified zones, i.e., Wuhan, Hubei Province excluding Wuhan, and mainland China excluding Hubei. We estimated the latent infection ratio to be around 0.12% (18,556 people) and the basic reproduction number to be 3.24 in Wuhan before the city's lockdown on January 23, 2020. The findings based on this debiasing framework have important implications to prioritization of control and prevention efforts.One Sentence Summary: A geo-stratified debiasing approach incorporating human movement data was developed to improve modeling of the 2019-nCoV epidemic.All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

In order to tackle the infeasibility of building mathematical models and conducting physical experiments for public health emergencies in the real world, we apply the Artificial societies, Computational experiments, and Parallel execution (ACP) approach to public health emergency management. We use the largest collective outbreak of H1N1 influenza at a Chinese university in 2009 as a case study. We build an artificial society to simulate the outbreak at the university. In computational experiments, aiming to obtain comparable results with the real data, we apply the same intervention strategy as that was used during the real outbreak. Then, we compare experiment results with real data to verify our models, including spatial models, population distribution, weighted social networks, contact patterns, students' behaviors, and models of H1N1 influenza disease, in the artificial society. In the phase of parallel execution, alternative intervention strategies are proposed to control the outbreak of H1N1 influenza more effectively. Our models and their application to intervention strategy improvement show that the ACP approach is useful for public health emergency management.Index Terms-Agent-based simulation, artificial societies, computational experiments, emergency management, parallel execution (ACP), public health.

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