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These observations support that PI3K/Akt pathway is highly activated in SIA, which may implicate therapeutic targeting of the PI3K/Akt signaling pathway for its treatment.

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Evaluating the capability of smart information service and exploring the smart information service elements in scenic areas can accelerate the smart tourism industry progress to a highly effective administrative and high quality of smart tourism service. This study aims to exploring the connections of a variety of smart information service elements in scenic areas, analyzing and evaluating the capability of smart information service, mapping a positive resolution to improve the capability of information service in scenic spots. Based on a synthetic method that combining Structural Equation Modeling (SEM) and Analytic Network Process (ANP), explicitly using the SEM to extracting the key factors and mapping each factors’ co-relations, and in further step, using the ANP to carry a fuzzy evaluation of weighing the information service capability and each element in the case of Jiangxi Province in China, the result shows that the method of “SEM-ANP” is better fit than single ”SEM” or ”ANP”, the evaluating system for smart information service in scenic areas is significantly innovative and scientific to supply effective suggestions for policy makers.