Traditional Chinese Medicine (TCM), with a history of thousands of years of clinical practice, is gaining more and more attention and application worldwide. And TCM-based new drug development, especially for the treatment of complex diseases is promising. However, owing to the TCM’s diverse ingredients and their complex interaction with human body, it is still quite difficult to uncover its molecular mechanism, which greatly hinders the TCM modernization and internationalization. Here we developed the first online Bioinformatics Analysis Tool for Molecular mechANism of TCM (BATMAN-TCM). Its main functions include 1) TCM ingredients’ target prediction; 2) functional analyses of targets including biological pathway, Gene Ontology functional term and disease enrichment analyses; 3) the visualization of ingredient-target-pathway/disease association network and KEGG biological pathway with highlighted targets; 4) comparison analysis of multiple TCMs. Finally, we applied BATMAN-TCM to Qishen Yiqi dripping Pill (QSYQ) and combined with subsequent experimental validation to reveal the functions of renin-angiotensin system responsible for QSYQ’s cardioprotective effects for the first time. BATMAN-TCM will contribute to the understanding of the “multi-component, multi-target and multi-pathway” combinational therapeutic mechanism of TCM, and provide valuable clues for subsequent experimental validation, accelerating the elucidation of TCM’s molecular mechanism. BATMAN-TCM is available at http://bionet.ncpsb.org/batman-tcm.

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Purpose – The purpose of this paper is to provide an in-depth overview of the security requirements and challenges for Internet of Things (IoT) and discuss security solutions for various enabling technologies and implications to various applications. Design/methodology/approach – Security requirements and solutions are analysed based on a four-layer framework of IoT on sensing layer, network layer, service layer, and application layer. The cross-layer threats are analysed followed by the security discussion for the enabling technologies including identification and tracking technologies, WSN and RFID, communication, networks, and service management. Findings – IoT calls for new security infrastructure based on the new technical standards. As a consequence, new security design for IoT shall pay attention to these new standards. Security at both the physical devices and service-applications is critical to the operation of IoT, which is indispensable for the success of IoT. Open problems remain in a number of areas, such as security and privacy protection, network protocols, standardization, identity management, trusted architecture, etc. Practical implications – The implications to various applications including supervisory control and data acquisition, enterprise systems, social IoT are discussed. The paper will serve as a starting point for future IoT security design and management. The security strategies for IoT should be carefully designed by managing the tradeoffs among security, privacy, and utility to provide security in multi-layer architecture of IoT. Originality/value – The paper synthesizes the current security requirements for IoT and provides a clear framework of security infrastructure based on four layers. Accordingly, the security requirements and potential threats in the four-layer architecture are provided in terms of general devices security, communication security, network security, and application security.

Nitrogen is fundamental to all life forms and is also one of the most limiting of nutrients for plant growth. Several clades of angiosperms have developed symbiotic relationships with actinorhizal bacteria that fix atmospheric nitrogen and increase access to this nutrient. However, the evolutionary patterns of actinorhizal nitrogen-fixing symbioses remain unclear to date. Furthermore the underlying environmental pressures that led to the gain of symbiotic actinorhizal nitrogen fixation have never been investigated. Here, we present the most comprehensive genus-level phylogenetic analysis of the nitrogen-fixing angiosperms based on three plastid loci. We found that actinorhizal nitrogen-fixing species are distributed in nine distinct lineages. By dating the branching events, we determined that seven actinorhizal nitrogen-fixing lineages originated during the Late Cretaceous, and two more emerged during the Eocene. We put forward a hypothesis that multiple gains of actinorhizal nitrogen-fixing symbioses in angiosperms may have been associated with increased global temperatures and high levels of atmospheric carbon dioxide during these two time periods, as well as the availability of open habitats with high light conditions. Our nearly complete genus-level time-tree for the nitrogen-fixing clade is a significant advance in understanding the evolutionary and ecological background of this important symbiosis between plants and bacteria.