Eucommiae Cortex (EC), a rare, nourishing medicinal herb that is native in China, has good effect in the treatment of hypertension. In this study, we compared tissue distribution of six representative active components of EC extract—genipinic acid (GA), protocatechuic acid (PCA), neochlorogenic acid (NCA), chlorogenic acid (CA), (+)-pinoresinol di-O-β-D-glucopyranoside (PDG), and (+)-pinoresinol 4′-O-β-D-glucopyranoside (PG)—between normal rats and spontaneously hypertensive rats (SHRs). Each rat was intragastrically given EC extract at a dose of 5.4 g/kg. Rats were sacrificed at 10 min, 30 min, 2 h, and 8 h after administration; six rats were sacrificed at each time point. Then, we quickly harvested their major organs, including heart, liver, spleen, lungs, kidneys, and brain. Using ultraperformance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS), we determined the levels of the above mentioned six components in the organs of both types of rats and then analyzed differences in the tissue distribution. The results showed that levels of each component differed between SHRs and the normal group at each time point. As time progressed, the number of organs in which GA distribution in each tissue of SHRs differed from that of the normal group gradually increased: SHRs showed lower GA levels than normal rats. Levels of PG and PDG in both groups at 10 and 30 min were similar. NCA and CA in the SHR group and the normal group at 10 min, 30 min, and 2 h were also similar to some extent. The results indicated that the pathological state of spontaneous hypertension could affect tissue distribution of EC active components in rats.

Objective: To determine the effects of a community hospital integrated model on the longitudinal management of diabetic patients.Methods: Four hundred forty-one patients with type 2 diabetes residing in Jingsong Community were randomly assigned to intensive and standard groups. Metabolic parameters were measured in the two groups at baseline and after 36 months of management to compare the rate of goal achievement.Results: After comprehensive management, the overall control rate in the intensive group was increased from 2.7% to 9.6% compared with 2.3%-4.5% in the standard group. Specifically, the control rates for fasting plasma glucose, glycosylated hemoglobin, and blood pressure in the intensive group were significantly increased from 54.1%, 40.0%, and 68.2% to 85.5%, 74.6%, and 89.1%, respectively. The control rate for glycosylated hemoglobin in the intensive group was significantly higher than the standard group after 36 months of treatment. Conclusion:The community hospital integrated model for longitudinal management effectively improved the control rate of glycosylated hemoglobin and the overall control rate in patients with type 2 diabetes.