Purpose: To investigate the clinical effect of sodium hyaluronate eye drops combined with tobramycin, dexamethasone, and pranoprofen eye drops in the treatment of dry eye after phacoemulsification. Methods: Medical records of 188 patients with dry eye after phacoemulsification, treated in our hospital from August 2020 to August 2021, were included and divided into groups based on the type of dry eye treatment. Patients in the control group ( n = 90) were treated with tobramycin, dexamethasone, and pranoprofen eye drops. Patients in the test group ( n = 98) were treated with sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops. The tear secretion test (TST), film rupture time (BUT), corneal fluorescence staining (FS) score, levels of interleukin (IL)-6, and tumor necrosis factor (TNF)-α before the treatment and at 1 month follow-up, the overall total effective rate and the number of completely cured cases were compared between the two groups. Multiple linear regression was used to calculate coefficients for predicting clinical variables. Ordinal logistic regression was used to compute coefficients and odds ratios for predicting effective scores. Results: The total effective rate in the observation group (99%) was significantly higher than that in the control group (80.00%). After the treatment, the TST and BUT indexes of the observation group were higher compared to the control group, and the FS score of the observation group was lower than that of the control group. TNF-α and IL-6 levels of the observation group were lower compared to the control group. Logistic regression analysis demonstrated that the differences in the effective rate and clinical variables between the two groups remained significant after adjusting for the effect of age. Conclusion: A combination of sodium hyaluronate, tobramycin, dexamethasone, and pranoprofen eye drops for the treatment of dry eye after phacoemulsification can improve the curative effect, reduce corneal fluorescein staining and inflammatory factor index levels compared to the treatment regimen lacking sodium hyaluronate eye drops.

This retrospective case–control study examined the association between the rs2071559 (-604T/C) single nucleotide polymorphism (SNP) in the vascular endothelial growth factor receptor (VEGFR)-2 gene and the risk of diabetic retinopathy (DR) in Northern Han Chinese. This study included patients diagnosed with diabetes mellitus (DM) in Shijiazhuang between 07/2014 and 07/2016. The healthy controls were unrelated individuals who received routine physical examinations. The diabetic patients were grouped as DM (diabetes but no fundus examination abnormalities), proliferative DR (PDR), and non-proliferative DR (NPDR). Finally, 438 patients were included: 114 controls and 123, 105, and 96 patients in the DM, NPDR, and PDR groups, respectively. In the multivariable analyses and all genetic models, the VEGFR-2 rs2071559 SNP was not associated with DR (among all diabetic patients) or with PDR (among the patients with DR) after adjustment for age, sex, duration of DM, blood glucose, systolic blood pressure, diastolic blood pressure, and body mass index (all P > 0.05). In conclusion, the VEGFR-2- 604T/C rs2071559 SNP is not associated with DR or PDR in the Han Chinese population of Shijiazhuang (China).

Objectives: To measure choroidal thickness (CT) in highly myopia eyes using enhanced depth imaging spectral-domain optical tomography (EDI SD-OCT) and explore the relationship between the CT and axial length (AL) and corneal curvature. Methods: This study assessed 66 eyes of 33 patients with both eyes of high myopia (equivalent sphericity ≥-6D or AL≥26mm) who underwent treatment at the department of ophthalmology, fourth hospital of Hebei Medical University from August 2020 to August 2021(High-myopia group). The control group included 54 eyes from 27 healthy volunteers. The patients in the two groups were 18~40 years old. EDI SD-OCT was used to measure the CT of subfoveal choroidal thickness (SFCT) and CT from fovea to nasal and temporal sides at an interval of 500~2500μm. The intraocular pressure, diopter, ocular axis, corneal curvature, and CT were compared between the two groups. The correlation between CT, diopter and AL was measured by Pearson’s r. Results: The diopter, AL, vertical corneal curvature, and CT in the high-myopia group were significantly higher than those in the control group (P<0.05). There was significant correlation between SFCT and AL in both groups (P<0.05). There was a negative correlation between AL and CT in high-myopia group (r=-0.395, P<0.05), and a positive correlation between AL and CT in control group (r=0.29, P<0.05). There was a weak correlation between AL and gender, intraocular pressure, and horizontal corneal curvature(P<0.05), and a negative correlation between AL and diopter (r=-0.861, P<0.001). Conclusion: EDI SD-OCT can quantitatively measure the CT of high myopia. The CT of patients with high myopia was significantly thinner than that of the control group of the same age. There was a significant correlation between diopter, AL and CT, suggesting that AL is a parameter indicating the degree of myopia, and the change of CT may play a role in the occurrence and development of high myopia. doi: https://doi.org/10.12669/pjms.38.7.6409 How to cite this:Lu H, Guan Y, Wei G, Li N. The relationship between choroidal thickness and axis length and corneal curvature in high myopia. Pak J Med Sci. 2022;38(7):1999-2004. doi: https://doi.org/10.12669/pjms.38.7.6409 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.