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Cannabinoid receptor type II (CB2 for short) is a subtype of cannabinoid receptor. At present, the three-dimensional conformation of CB2 protein has not been determined. In this paper, a protein folding method of CB2 based on HP model and genetic algorithm are proposed, which can help to study the folding mechanism and pharmacological properties of CB2. By using the backtracking mechanism, the genetic algorithm, which can help to solve this optimization problem, can help to avoid local optimization. The folding results obtained by the algorithm are analysed and compared. The experimental results demonstrate that the CB2 conformation obtained by genetic algorithm has a lower energy value, which is a good basis for further research on CB2 folding mechanism.