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In this paper, after reviewing the researches about the influence of transportation infrastructure on regional economy, it is pointed out that the influence of the transportation infrastructure on regional economy can be illustrated by network effects and spatial spillovers. A panel data model is estimated using data from Hebei economy almanac in the intervals 2007-2017. And the result shows that the interaction between economic growth and highway infrastructure is significant, and the impact of highway infrastructure on economic growth is greater. Finally, this paper suggests that the selections of variables, scopes of regions, and model dynamics can be taken into further consideration in the future.