This study aimed to investigate the technology preparedness of Grade 10 students as to their collaborative and creative thinking skills. Specifically, it determined the extent of technology preparedness in mixed learning environment in terms of performance expectancy, effort expectancy, facilitating conditions, and social influence, the level of collaboration and creative thinking skills in learning science and the relationships of technology preparedness as to collaborative and creative thinking skills. The study employed descriptive correlational research through the utilization of self-made questionnaire to measure the students’ technology preparedness. Meanwhile, the assessment of the collaboration and creative thinking skills, different activities with rubrics were used. The findings revealed that the students are were moderately prepared in technology but they were proficient in learning science. The study further showed significant relationship between the student’s technology preparedness and some skills in collaboration and creative thinking skills. With this finding, it is recommended that collaborative and creative thinking skill activities as a teaching method be used in classes across levels and programs.