BackgroundWe have previously shown that oxidized linoleic acid significantly lower plasma triglyceride (TG) levels as compared to animals fed oleic acid, the changes was associated with increased APOA5 and acetyl‐CoA oxidase genes expression in the mice. The focus of the current study is to determine the mechanisms and plasma and tissue metabolites associated with the plasma triglycerides decreased levels.Study DesignWe fed C57BL6 normal male mice 4 groups (N=10 each) 4 different types of mouse diet formulations as follows: normal mouse chow (P), normal chow supplemented with 18 mg/day linoleic acid (C), oxidized linoleic acid 9 mg (A) or 18 mg /animal/day) for 2 months. Mice were sacrificed; blood and tissues (liver, adipose, kidney, and heart) were collected. We measured the plasma lipids, performed Western Blot for the Apo5, ApoC3 and related proteins expression.Results and ConclusionThis is a going study, we currently completed the plasma APoC3 measurements; as anticipated our data have shown a significant dose dependent decreases in plasma ApC3 on mice fed low (P<0.01) and high (P<0.003) dose oxidized linoleic acid compared to the control group on linoleic acid. These finding indicate for the first time that intake of oxidized linoleic acid decreases plasma ApoC3 levels and modulatesplasma TG..