According to the data shown in Table 1, (3) has the same structure as the analogous cyclopentadienyl compound [4, ' ' 1 having no substituent in the five-membered ring. Complex (3) decomposes both thermally (ISOOC, 1 h) and photochemically (tetrahydrofuran, Hg high-pressure lamp, A > 300 nm) via carbonyl elimination to form (1) and the twofold carbonyl-bridged derivative (4). Maitlis et al. obtained (4) by heating (1) (80-85 "C/10-20 torr)[''; however, (4) does not form photochemically. Carbonylation of (4) under normal pressure essentially affords the starting material (1) along with very small amounts of (3).The carbonylrhodium compound (3) which in fact is inaccessible by thermal or photochemical (dimerizing) decarbonylation of (1) can readily be obtained by the protonation/ deprotonation sequence presented in this communication.Owing to the basic character of (1) and analogous metal-car-bony1 systems, their acid activation constitutes a clear-cut method for the facile construction of polynuclear complexes which can be obtained only with difficulty, in only low yields, or not at all by conventional methodsf61. Procedure['1(2): To a vigorously stirred solution of (1)Ix1 (294 mg, 1.0 mmol) in diethyl ether (20 ml) is added dropwise 54% HBF4 (ca. 0.2 ml) in the same solvent. Towards the end of acid addition, compound (2) deposits as a dark brown floccular precipitate which is quickly filtered off on a D3 frit, washed with ether (4 x 6 ml), and dried for 3 h in a high vacuum; yield 298 mg (92%).(3): Compound (2) (298 mg, 0.46 mmol) is treated with a saturated NaOCH3/CH30H solution (6 ml) in the dark at

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BACKGROUND Survival after first‐line therapy is poor for patients with glioblastoma. The role of second‐line treatment for recurrent disease is controversial. The authors studied the outcome in a subset of patients with glioblastoma who were selected for an aggressive reintervention strategy at the time of progression. Their objectives were to improve patients' overall survival with sustained quality of life and to make comparisons with overall survival in unselected patients. METHODS Overall, 168 patients were eligible for retrospective analysis. Ninety patients received specific therapy for disease recurrence (reintervention group) by specific criteria. RESULTS In the reintervention group, promising median overall survival (mOS) results after diagnosis (61.5 weeks) and progression (33 weeks) were obtained. The progression‐free survival (PFS) rate at 12 months and the overall survival rate were superior in the reintervention group (71% at 12 months and 32% at 24 months) compared with the total cohort (45% and 20%, respectively) and the standard group (15% and 5%, respectively). A matched‐pair analysis (n = 46 in each group), with an mOS period of 65.5 versus 28.5 weeks, confirmed these data. Quality of life was stable or slightly improved during reinterventions in a subset of patients treated within clinical studies. CONCLUSIONS The majority of patients in the current series were treated with a reintervention strategy, which had an impact on PFS and mOS. A second resection, focal radiotherapy (in selected cases), and additional chemotherapeutic regimens should be considered for patients with recurrent glioblastoma. Cancer 2003;98:2678–86. © 2003 American Cancer Society.

Introduction: In clinical practice, evaluation of postural control is based on the neurological examination, including Romberg's test, examination of gait and performance of pull test as part of the Unified Parkinson's Disease Rating Scale (UPDRS). The goal of our study was to identify posturographic parameters since quantitative technical methods for the measurement of postural control are not established in clinical routine yet. Methods: In this cross-sectional study design we examined patients with Parkinson's disease (PD) (Hoehn and Yahr < 3; PD n = 12) on a static posturographic platform (eyes open and eyes closed), performing a standard Romberg's test during neurological examination and compared the results with an age-matched healthy adult control (HAC n = 10) and a healthy young control (HYC n = 21). Results: In the platform Romberg's test with open eyes, the patients with PD showed a significantly greater mean sway [PD: 14.98 vs. HAC: 8.77 (mm), p < 0.003 vs. HYC 7.80 (mm)], greater mean radius [PD: 28.31 vs. HAC: 16.36 (mm), p < 0.008 vs. HYC: 14.19 (mm)] and greater marked area [PD: 2.38 vs. HAC: 0.88 (cm2), p < 0.016 vs. HYC: 0.78 (cm2)] compared to the HAC. The Romberg's test with closed eyes revealed a significantly greater mean sway [PD: 13.83 vs. HAC: 10.12 (mm), p < 0.033 vs. HYC: 5.82 (mm)] and greater mean radius [PD: 25.03 vs. HAC: 18.15 (mm), p < 0.045 vs. HYC: 9.11 (mm)] compared to both groups. Conclusions: The platform Romberg-test with closed eyes detected significant differences in elderly people and patients with Parkinson's disease, which could be objectively quantified with static posturography testing. Age alone showed significant changes, only detectable with closed eyes. Therefore, balance testing with a new computerized approach could help to identify balance problems in a geriatric assessment in clinical routine, especially with the parameters marked area and mean sway.