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This study investigates the application of precipitation estimation from remote sensing information using artificial neural networks (PERSIANN) for hydrological modeling over the Russian River catchment in California in the United States as a case study. We evaluate two new PERSIANN products including the PERSIANN-Cloud Classification System–Climate Data Record (CCS–CDR), a climatology dataset, and PERSIANN–Dynamic Infrared Rain Rate (PDIR), a near-real-time precipitation dataset. We also include older PERSIANN products, PERSIANN-Climate Data Record (CDR) and PERSIANN-Cloud Classification System (CCS) as the benchmarks. First, we evaluate these PERSIANN datasets against observations from the Climate Prediction Center (CPC) dataset as a reference. The results showed that CCS–CDR has the least bias among all PERSIANN family datasets. Comparing the two near-real-time datasets, PDIR performs significantly more accurately than CCS. In simulating streamflow using the nontransformed calibration process, EKGE values (Kling–Gupta efficiency) for CCS–CDR (CDR) during the calibration and validation periods were 0.42 (0.34) and 0.45 (0.24), respectively. In the second calibration process, PDIR was considerably better than CCS (EKGE for calibration and validation periods ~ 0.83, 0.82 for PDIR vs. 0.12 and 0.14 for CCS). The results demonstrate the capability of the two newly developed datasets (CCS–CDR and PDIR) of accurately estimating precipitation as well as hydrological simulations.

Background:During adolescence, sex hormones play an important role in regulating proliferation, differentiation, maturation, and the scheduled death of chondrocytes. Although some studies have reported the regulatory role of estrogen in the development and progression of cartilage, some of the mechanisms still remain unclear, including the role of estrogen in the expression of cartilage-specific genes in chondrogenesis process, which we cover in this study.Materials and Methods:In the present study, we used adipose-derived stem cells (ADSCs) to differentiate into cartilage. Differentiated cartilage cells were used in the control (without estrogen E2 in the culture medium) and experimental (with estrogen in the culture medium) groups to evaluate the expression of type II collagen and aggrecan as chondrogenic genes markers, with -real-time polymerase chain reaction technique.Results:Our results indicated that estrogen leads to inhibition of type II collagen gene expression and reduction of aggrecan gene expression.Conclusion:Therefore, estrogen probably has negative effects on chondrogenesis process of ADSCs.

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