The contents of this page will be used as part of the graphical abstract of html only. It will not be published as part of main. A new series of nitric oxide-donating fluoroquinolone/oximes was prepared in this study. Evaluation of their antitubercular activity revealed that ketone derivatives 2b and 2e and oximes 3b and 3d exhibited somewhat higher activity than their respective parent fluoroquinolones. More important, oximes 3c-e are highly potent against Klebsiella pneumoniae, whereas ketone 2c and oxime 4c are more active against Staphylococcus aureus than ciprofloxacin.

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Oximes and nitrate esters are considered as important nitric oxide (NO) donors with diverse biological activities. Herein, we report the synthesis and characterization of new oxime and nitrate ester derivatives of norfloxacin as potential NO donor hybrids with expected synergistic antimicrobial activity. The release of NO from those hybrids was measured by a modified Griess method in which p-nitroaniline was employed instead of sulfanilamide. The increased electrophilicity of the intermediate 4-nitroaniline diazonium salt accelerated the coupling process and shortened the overall assessment time. The improved detection limits and enhanced sensitivity would pave the way for the future application of this method in nitrite determination in biological or non-biological systems.

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