Drug abuse as a biological, psychological, and social problem affect all life aspects including quality of life and cause socio-psychological problems. This study aimed to evaluate the effectiveness of community reinforcement and family training (CRAFT) Method on quality of life and depression in family members of substance abusers. This was a quasi-experimental study with control group in which the pre-test and post-test were used. In the present study, two experimental groups (CRAFT and Nar-Anon) and a control group were used using the purposive sampling selected from the family members of substance abusers who referred to the methadone treatment clinic in Tehran. Each of groups consisted of 25 people. CRAFT groups were trained in 12 sessions of intervention techniques. Nar-Anon groups participated in self-help sessions and control did not receive any training. All three groups completed the BDI-II Test and WHO Quality of Life-BREF questionnaire and the results were analyzed using SPSS-16. The results of two intervention methods compared with the control group showed no significant effect in reducing depression. CRAFT and Nar-Anon interventions were not effective in reducing the depression of family members of drug abuse patients but both were effective in promoted the quality of their life compared with control group.