The effect of CeO 2 doping on structure and catalytic performance of Co 3 O 4 catalyst was studied for lowtemperature CO oxidation. The Co 3 O 4 catalyst was prepared by a precipitation method and the CeO 2 /Co 3 O 4 catalyst was prepared by an impregnation method. Their catalytic performance had been studied with a continuous flowing microreactor. The results reveal that the CeO 2 /Co 3 O 4 catalyst exhibits much better resistance to water vapor poisoning than the Co 3 O 4 catalyst for CO oxidation. The CeO 2 /Co 3 O 4 catalyst can maintain CO complete conversion at least 8,400 min at 110°C with 0.6% water vapor in the feed gas, while the Co 3 O 4 catalyst can maintain at 100% for only 100 min. Characterizations with XRD, TEM and TPR suggest that the CeO 2 /Co 3 O 4 catalyst possesses higher dispersion degree, smaller particles and larger S BET , due to the doping of Ceria, and exists the interaction between CeO 2 and Co 3 O 4 , which may contribute to the excellent water resistance for low-temperature CO oxidation. Furthermore, the H 2 detected in the reactor outlet gas seems to indicate that the water-gas shift reaction is the more direct reason.