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Introduction: Behçet’s disease is a systemic variable vessel vasculitis with unknown cause. Neurologic involvement known as neuro-Behcet’s disease (NBD) is often diagnosed in patients who present neurological symptoms and radiological lesions of the central nervous system. Case Report: A 42-year-old woman with a history of orogenital ulceration presented with behavioral disorders and heaviness of left hemibody. Brain magnetic resonance imaging (MRI) was performed and showed a pseudo-tumor diencephalo-mesencephalic area with T2 and Flair hypersignal, a slight hypersignal in diffusion sequence, and no contrast uptake. Conclusion: Pseudotumoral NBD is a rare but severe manifestation of Behçet’s disease. Cerebral MRI is the most efficient method to explore, detect, and monitor parenchymal lesions.

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