Background: Staphylococcus aureus (S. aureus) nasal carriage may be responsible for some serious infections in hemodialyzed patients. It is incriminated as the most common aetiologic agent in CRBSI. Aim: To study the rate of staphylococcal nasal carriage in a sample of Egyptian maintenance HD patients, its relation to CRBSI and the patterns of culture and sensitivity in the nasal swabs and blood cultures. Patients and Methods: Nasal swabs were collected from 40 patients who were receiving maintenance hemodialysis with inserted temporary dialysis catheters and who did not receive any antibiotics during the previous week. Nasal swabs with subsequent culture on blood agar and blood cultures from the catheters were done for all included patients. Results: Our results showed that (81.8%) of the participants who had Positive blood culture had positive nasal swab, participants with positive nasal swab are 1.818 times more liable to develop positive blood culture than patients with negative nasal swab (RR=1.818; 95%CI= (1.125-2.940). Results show that coagulase negativeStaphylococci were the most frequent organism found in central blood culture (45.5%), followed by coagulase positive Staphylococci (36.4%), E.coli and Pseudomonas each accounted for (9.1%). Results showed that organisms retrieved from nasal swabs were most sensitive to vancomycin & Clindamycin (94.4% & 77.8%) respectively while 77.8% were resistant to Cefoxitin and 72.2% were resistant to Erythromycin & Trimetoprim/sulfamethoxazole respectively, and show that organisms retrieved from blood were most sensitive to Vancomycin, Doxycycline & Clindamycin (100.0%, 90.9% & 81.8%) respectively while 100.0% were resistant to Trimetoprim/ sulfamethoxazole and 63.7% were resistant to Cefoxitin, Gentamycin and Erythromycin. Conclusion: Staphylococcal infection accounts for the majorityof cases of CRBSIs, to a lesser extent gram negative organisms. Staphylococcal nasal carriage is a strong predictor of CRBSI. Culture and sensitivity results retrieved from nasal swabs and blood cultures showed a similarity in being both sensitive to vancomycin and clindamycin, and resistant to Trimetoprim/sulfamethoxazole.