Only a limited number of studies on cellulite have been published in the international literature and many of them reach somewhat antithetical conclusions. Consequently, it is not yet possible to reconcile the extreme differences of opinion which have lingered on for years concerning the nature of this disorder, as well as its origin and even the most basic aspects of its histopathological classification. It does not even have a recognized name: in fact, the term 'cellulitis' is used in scientific English to indicate a spreading gangrenous infection of the subcutaneous cellular tissue. The other terms used from time to time [panniculitis, lipodystrophy, edematofibrosclerotic panniculitis (EFP), liposclerosis, lipoedema, etc.] have quite different morphological and pathogenetic connotations in general. Over the last few decades, three major conflicting theories have emerged in relation to the ethiopathogenesis of cellulite. These indicate, respectively, the following causes: 1. Oedema caused by excessive hydrophilia of the intercellular matrix. 2. A homeostatic alteration on a regional microcirculatory level; this pathogenetic theory is summarized in a synthetic and self-explanatory denomination: EFP. 3. A peculiar anatomical conformation of the subcutaneous tissue of women, different from male morphology.These theories must all now be updated in the light of recent advances on the sophisticated and composite physiopathology of the adipose organwhich acts not only as a control device which regulates the systematic equilibrium of energy and modulates the food intake and the metabolism of other tissue substrate through a multiple glandular secretion of hormones and parahormones. Ré suméSeulement un nombre limité d'études sur la cellulite a été publié dans la littérature internationale et beaucoup de ces articles arrivent à des conclusions plutôt antithétiques. Par conséquent, actuellement il est impossible de reconcilier les opinions extrèmement différentes concernant la nature de ce désordre, ainsi que son origine, de même que les aspects les plus basilaires de sa classification histopathologique. Le nom même de cette affection n'est pas reconnu: en fait le terme '' cellulite ''est utilisé dans le language scientifique pour indiquer une inflammation du tissu cellulaire sous-cutané, d'origine infectieuse. Les autres termes employés de temps an temps tels que panniculopathie, lipodystrophie, panniculopathie oedémato-fibroscléreuse, liposclérose, lipoedème etc. ont en general des connotations morphologiques e pathogénétiques tout à fait différentes. Au cours des dernières décen-nies, trois principales théories contradictoires ont émergé pour ce qui concerne l'etiopathologie dela cellulite. Chacune théorie indique respectivement les suivantes causes:

This Stimuli article provides general information about the test methods that should be employed to ensure the quality and performance of topical and transdermal drug products. The term topical drug products refers to all formulations applied to the skin except transdermal delivery systems or transdermal patches that will be addressed separately.

No abstract

No abstract

The disposition and metabolic fate of 14C-oxandrolone (17a-methyl-17f3-hydroxy-2-oxa-5«-androstan-3-one)