Background: Xanthogranulomatous cholecystitis is a benign disease of gallbladder which presents almost classically similar with the chronic calculus cholecystitis, but it mimics GB carcinoma intraoperatively. Materials and methods:In our study, 54 cases were found in a study period of 2 yr in which histopathological reports was xanthogranulomatous cholecystitis whether the pt underwent lap/radical/open or lap converted open cholecystectomy for cholelithiasis and chr. cholecystitis and suspicious carcinoma GB. They were retrospectively analysed for getting an idea preoperatively to differentiate them on clinicoradiological ground and while during surgery. Datas were Results and Observation: retrospectively analysed and observed that clinical and biochemical features are non specic. Imaging in the form of USG and CT does help but not to that much extent to accurately diagnose them. intraoperatively presence of dense adhesion and loss of fat plane to surrounding structures creates a big dilemma for the operating surgeon and multiple frozen section biopsy can be of immense help here in guiding further treatment course .Frozen section analysis was not present at our institution so we did not avail its use. Our study is an attempt to derive any correlation Conclusion: between clilnicoradiological and intraoperative aspects preoperatively for the diagnosis of xanthogranulomatous cholecystitis. Although its incidence is greater here than other countries due to rising gallbladder diseases but till this time it is concluded that neither clinical nor radiologically xanthogranulomatous cholecystitis can be ruled out preoperatively. Only histopathological diagnosis is absolutely correct, and in our study we concluded that histopatholigal diagnosis is still the gold standard.