Accurate lesion detection in computer tomography (CT) slices benefits pathologic organ analysis in the medical diagnosis process. More recently, it has been tackled as an object detection problem using the Convolutional Neural Networks (CNNs). Despite the achievements from off-the-shelf CNN models, the current detection accuracy is limited by the inability of CNNs on lesions at vastly different scales. In this paper, we propose a Multi-Scale Booster (MSB) with channel and spatial attention integrated into the backbone Feature Pyramid Network (FPN). In each pyramid level, the proposed MSB captures fine-grained scale variations by using Hierarchically Dilated Convolutions (HDC). Meanwhile, the proposed channel and spatial attention modules increase the network's capability of selecting relevant features response for lesion detection. Extensive experiments on the DeepLesion benchmark dataset demonstrate that the proposed method performs superiorly against stateof-the-art approaches.

The current outbreak of coronavirus disease 2019 (COVID-19) has recently been declared as a pandemic and spread over 200 countries and territories. Forecasting the long-term trend of the COVID-19 epidemic can help health authorities determine the transmission characteristics of the virus and take appropriate prevention and control strategies beforehand. Previous studies that solely applied traditional epidemic models or machine learning models were subject to underfitting or overfitting problems. We propose a new model named Dynamic-Susceptible-Exposed-Infective-Quarantined (D-SEIQ), by making appropriate modifications of the Susceptible-Exposed-Infective-Recovered (SEIR) model and integrating machine learning based parameter optimization under epidemiological rational constraints. We used the model to predict the long-term reported cumulative numbers of COVID-19 cases in China from January 27, 2020. We evaluated our model on officially reported confirmed cases from three different regions in China, and the results proved the effectiveness of our model in terms of simulating and predicting the trend of the COVID-19 outbreak. In China-Excluding-Hubei area within 7 days after the first public report, our model successfully and accurately predicted the long trend up to 40 days and the exact date of the outbreak peak. The predicted cumulative number (12,506) by March 10, 2020, was only 3·8% different from the actual number (13,005). The parameters obtained by our model proved the effectiveness of prevention and intervention strategies on epidemic control in China. The prediction results for five other countries suggested the external validity of our model. The integrated approach of epidemic and machine learning models could accurately forecast the long-term trend of the COVID-19 outbreak. The model parameters also provided insights into the analysis of COVID-19 transmission and the effectiveness of interventions in China.

Embedding-based entity alignment has been widely investigated in recent years, but most proposed methods still rely on an ideal supervised learning setting with a large number of unbiased seed mappings for training and validation, which significantly limits their usage. In this study, we evaluate those state-of-the-art methods in an industrial context, where the impact of seed mappings with different sizes and different biases is explored. Besides the popular benchmarks from DBpedia and Wikidata, we contribute and evaluate a new industrial benchmark that is extracted from two heterogeneous knowledge graphs (KGs) under deployment for medical applications. The experimental results enable the analysis of the advantages and disadvantages of these alignment methods and the further discussion of suitable strategies for their industrial deployment.

Calcified plaque in coronary arteries is one major cause and prediction of future coronary artery disease risk. Therefore, the detection of calcified plaque in coronary arteries is exceptionally significant in clinical for slowing coronary artery disease progression. At present, the Convolutional Neural Network (CNN) is exceedingly popular in natural images’ object detection field. Therefore, CNN in the object detection field of medical images also has a wide range of applications. However, many current calcified plaque detection methods in medical images are based on improving the CNN model algorithm, not on the characteristics of medical images. In response, we propose an automatic calcified plaque detection method in non-contrast-enhanced cardiac CT by adding medical prior knowledge. The training data merging with medical prior knowledge through data augmentation makes the object detection algorithm achieve a better detection result. In terms of algorithm, we employ a deep learning tool knows as Faster R-CNN in our method for locating calcified plaque in coronary arteries. To reduce the generation of redundant anchor boxes, Region Proposal Networks is replaced with guided anchoring. Experimental results show that the proposed method achieved a decent detection performance.

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