ITGBL1 promotes gastric cancer proliferation leading cause of cancer death globally especially in East Asia (1-3). Despite advances in diagnostic, surgical techniques for its removal, and moleculary targeted drugs, the 5-year overall survival rate of patients with GC is still very low due to the unclarified molecular mechanisms underlying GC tumorigenesis and its progression (1). Therefore, investigations at the molecular level to better understand the underlying mechanism of oncogenesis are indispensable for improving diagnosis, prognosis, and treatment of this form of cancer.ITGBL1 promotes gastric cancer proliferation 690

Multiple primary malignant neoplasms (MPMNs) are defined as multiple tumors with different pathogenic origins. MPMNs are rare, but the morbidity rate is on the rise. With the development of anti-tumor treatments, such as targeted therapy and immunotherapy, the overall survival of cancer patients has been significantly prolonged, leading to an increased number of patients with MPMNs. A crucial aspect of MPMNs management is deciding how to schedule further treatments according to individual tumor risk. This process involves a multidisciplinary physician team to ensure favorable outcomes. Herein we report a 60-year-old male who developed four different malignancies, including esophageal squamous cell carcinoma, upper urinary tract urothelial carcinoma, mediastinal small cell lung cancer, and left lung squamous cell carcinoma over 20 years and received appropriate treatment of each cancer with long survival.