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In this paper, the cleanroom fire simulation in a semi-conductor factory is investigated by using the commercial computational fluid dynamics (CFD) code. We using three different combustion models in the fire simulation. The combustion models including the volume heat source (VHS) model, the eddy break-up (EBU) model and the presumed probability density function (prePDF) model are considered to predict the cleanroom fire. The turbulence models coupled with different combustion models, while the radiation model is coupled with the turbulent combustion processes. Additionally, the discrete transfer radiation method (DTRM) is used in the global radiation heat exchange. For the fire simulation, the different combustion models are evaluated for their performance and compared with the experimental data from the literature to verify. Thus, these numerical simulations can be adopted as a useful tool to design and optimize the smoke control strategy in cleanroom fire.