A previous study revealed that protein tyrosine phosphatase receptor type D (PTPRD) is highly associated with diabetes mellitus, particularly for type 2 diabetes, through a genome-wide association study. However, the influence of the human polymorphism in the 3'-untranslated region (3'-UTR) of PTPRD on gestational diabetes mellitus (GDM) has remained to be defined. The present study focused on the functional polymorphism located in the 3'-UTR of PTPRD and whether it is associated with the susceptibility to develop GDM. A total of 1,100 pregnant female patients aged between 28 and 36 years within gestational weeks 24-28 were recruited. The participants enrolled in the study comprised 500 cases of GDM and 600 normal controls. Based on the screening results, the single nucleotide polymorphism (SNP) rs56407701 exhibited the most significant difference and may increase the susceptibility to GDM. A prediction of target microRNAs (miRNAs/miRs) using the miRNA SNP database indicated that SNP rs56407701 may be bound by miR-450a, causing the suppression of PTPRD expression in subjects with the GC or CC genotype. In conclusion, The CC genotype of PTPRD rs56407701, which may be bound by miR-450a, may increase the susceptibility of Chinese Han females to GDM during pregnancy. The present study provided a theoretical basis for the SNP rs56407701 being a source of GDM susceptibility loci.
Stauntonia obovatifoliola subsp. urophylla belongs to Lardizabalaceae. It is woody vine, with fine lines on its stems, branches, and petioles. In China, they are mainly distributed in Fujian, Guangdong, Guangxi, Jiangxi, Hunan, and Zhejiang. Here, we report and characterize the complete plastid genome sequence of S. obovatifoliola subsp. urophylla in an effort to provide genomic resources useful for promoting its systematics research. The complete plastome of S. obovatifoliola subsp. urophylla is 158,944 bp in length, including two Inverted Repeat (IR) regions of 26,284 bp, a Large Single-Copy (LSC) region of 87,306 bp and a Small Single-Copy (SSC) region of 19,070 bp. The plastome contains 115 genes, consisting of 80 unique protein-coding genes, 31 unique tRNA genes, and four unique rRNA genes. The overall A/T content in the plastome of S. obovatifoliola subsp. urophylla is 61.40%. The complete plastome sequence of S. obovatifoliola subsp. urophylla will provide a useful resource for the conservation genetics of the species as well as for the phylogenetic studies of the genus Stauntonia.
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