Background: Triclosan (TCS) is an environmental chemical with endocrine disrupting effects and can enter the body through the skin or oral mucosa. Human data about the effect of TCS exposure during pregnancy on neonatal birth weight and TCS exposure during childhood on children's growth are scarce.Objectives: To investigate the association between maternal urinary TCS level and neonatal birth weight, as well as children's urinary TCS level and children's body mass index (BMI).Methods: A systematic literature search was conducted using PubMed, Cochrane Library, and Web of Science. Finally, seven epidemiological articles with 5,006 participants from September 25, 2014 to August 10, 2018 were included in the meta-analysis to identify the relationship between maternal exposure to TCS and neonatal birth weight. On the other hand, three epidemiological articles with 5,213 participants from July 22, 2014 to September 1, 2017 were included in another meta-analysis to identify the relationship between children's exposure to TCS and children's BMI. We used Stata 16.0 to test the heterogeneity among the studies and calculating the combined effect value 95% confidence interval (CI) of the selected corresponding models.Results: TCS exposure during pregnancy was not significant associated with neonatal birth weight. The results of forest plots were as follows: ES (Estimate) = 0.41 (95% CI: −11.97–12.78). Children's urinary TCS level was also irrelevant associated with children's BMI: ES = 0.03 (95% CI: −0.54–0.60).Conclusions: This meta-analysis demonstrated that there was no significant association between maternal TCS level and neonatal birth weight, also there has no relationship between children's urinary TCS level and children's BMI.

Introduction:It is known that Cardiomyocytes cannot regenerate after birth. Loss of cardiomyocytes leads to regional contractile dysfunction and necrosis. Cardiomyocytes in infracted ventricular tissues are progressively replaced by fibroblasts in the form of scar tissues, which leads to contractile function disorder, decreases heart function and induces congestive heart failure.. This study aims to explore an experimental research of bone mesenchymal stem cells' differentiation, into cardiac cells induced by BMP-2. Methods: The bone marrow stem cells were taken from Meishan swines respectively. The 4 th generation of MSCs, immunocytochemistrically stained by cTnT, CX-43 and MHC, was induced by BMP-2for 24 hours. 15 healthy male Meishan swines were randomly divided into 3 groups, and heart infarction model was established with gelatin sponge through intervention. Group A was a control group, in which 5ml of DMEM was transplanted into infarction area through intervention 4 weeks later. 1×10 7 MSCs were transplanted into infarction zone in Group B. 1×10 7 induced MSCs were transplanted in Group C. The heart function was measured through Powerlab after transplanting. The number of neogenesis blood capillary was counted by factor VIII staining. The experiment of the research detected the expression of GATA-4 in all groups through the method of Western blot, observed the change of myocardial ischemia by ECT, and calculated the change of infarction area by the method of TTC as well. Results: There were some changes in the shape and arrangement of cells after induction with BMP-2, which activated the expression of cTnT and Cx-43 three weeks later. The dense and striation-like structure of cTnT was obvious 4 weeks later. Cx-43 was detected beneath the membrane three weeks after induction, while the granular and dense protein was observed at cell conjunction in four weeks. Moreover, there was expression of MHC endochylema and nucleus three weeks after induction. Powerlab showed that hemodynamic LVDP and ± dp/dtmax dropped significantly in cardiac infarction model before transplantation. As time went by, cardiac function of Group B and C improved a lot due to the transplantation of induced cells to infracted area and the improvement was more obvious in Group C (Pï¼oe0.05). Compared with Group A and B, the number of capillaries increased, infarction size decreased significantly (Pï¼oe0.05), the expression of GATA-4 was obvious 4 weeks after transplantation (Pï¼oe0.05), and ECT showed that ischemic area decreased obviously in Group C as well. Conclusion: BMP-2 could effectively induce myocardial cell differentiation of MSCs , the induced cells could promote new angiogenesis. and improve the ability of local contraction and heart function and reduced infarction area as well.