Background: Since the outbreak of the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in December 2019, it has affected >200 countries, areas, or territories in 6 continents. At present, whether COVID-19 has an effect on cardiovascular system is unclear. The aim of this study was to evaluate Fibrinogen level in iraqi patients with COVID-19 with Coronary artery disease. Methods:  Clinical features, laboratory results, and real time PCR were reviewed for 30 patients with laboratory-confirmed COVID-19 without a history of Coronary artery disease and 30 patients with laboratory-confirmed COVID-19 with Coronary artery disease. They were admitted to the Al-amal Hospital for participating; Iraq between October 2021-April 2022. Healthy participants who underwent routine physical checkups and non-COVID-19 patients the study as the control group. Fibrinogen and Apolipoprotein B levels were determine and compared between the Coronary artery disease COVID-19 and control groups. Results: Fibrinogen higher than the normal range of the patients with Coronary artery disease COVID-19 Compared to the control group. The levels of D.dimer and Ferretin of the patients with Coronary artery disease COVID-19 were significantly higher than those of the healthy control group.