Bibliometric analysis highlights key topics and publications that have shaped the understanding and management of esophageal cancer (EC). Here, the 100 most cited manuscripts in the field of EC are analyzed. The Thomson Reuters Web of Science database with the search terms 'esophageal cancer' or 'esophageal carcinoma' or 'oesophageal cancer' or 'oesophageal carcinoma' or 'gastroscopy' was used to identify all English language full manuscripts for the study. The 100 most cited papers were further analyzed by topic, journal, author, year, and institution. A total of 121,556 eligible papers were returned and the median (range) citation number was 406.5 (1833 to 293). The most cited paper focused on the role of perioperative chemotherpy in EC (1833 citations). Gastroenterology published the highest number of papers (n = 15, 6362 citations) and The New England Journal of Medicine received the most citations (n = 12, 12125 citations). The country and year with the greatest number of publications were the USA (n = 50), and 1998, 1999, and 2000 (n = 7). The most ubiquitous topic was the pathology of EC (n = 66) followed by management of EC (n = 54), and studies related to EC prognosis (n = 44). The most cited manuscripts highlighted the pathology, management, and prognosis of EC and this bibliometirc review provides the most influential references serving as a guide to popular research themes.

Aims: A bibliometric analysis identifies the major publications that influence the clinical management of Hepatocellular Carcinoma (HCC). Within this study, the 100 most cited HCC articles are noted and analysed. Methods: The search terminology “Hepatocellular carcinoma” and “HCC” were used to search through the Thomson Reuters Web of Science database. The inclusion criteria consisted of English language full articles. The subject matter, author and institution details, year of publication and journal were recorded for the 100 most cited HCC articles. Citation rate index was calculated by dividing the number of citations by the number of years since publication. Results: The search through the Thomson Reuters Web of Science database identified 39,518 eligible papers. The median (range) citation number was 909 (4419 to 458). The most cited article (produced by Llovet et al) discussed the role of Sorafenib in advanced HCC (4419 citations). Hepatology published the most articles (n=20, 20,533 citations), however the Lancet had the overall highest citation number of 39219, across 9 published articles. The most discussed topic was HCC management (n=31), followed by prognosis (n=18) and aetiology (n=15). Conclusion: This bibliometric analysis has identified the 100 most cited HCC articles. Through integrating new knowledge into clinical practice, this has enabled novel treatment strategies to be utilised for patients with HCC. This study highlights what makes a citable article and may aid in the development for future HCC research themes.