In this work, we demonstrate that water-soluble conjugated polymers (PFP) have the ability to inhibit biofilm formation and eradicate mature established biofilm using reactive oxygen species (ROS) produced by PFP under white light irradiation. Upon addition of PFP to planktonic Staphylococcus aureus (S. aureus), electrostatic interactions bring cationic PFP to the surface of S. aureus, which possesses negative charges. As the amount of PFP coated on S. aureus becomes saturated, the interactions of bacteria to bacteria and bacteria to surface may be disrupted, resulting in reduced biofilm formation. After the biofilm matures, those PFP on the surface of the biofilm can generate ROS under white light irradiation, which has the ability to inactivate bacteria nearby. Once the biofilm is broken, PFP can penetrate throughthe biofilm and continuously generate ROS under irradiation, resulting in biofilm disruption. As a consequence, this makes conjugated polymers a very promising material for the disruption of biofilm in biomedical and industrial applications.

Of the seven P2X receptor subtypes, P2X4 receptor (P2X4R) is widely distributed in the central nervous system, including in neurons, astrocytes, and microglia. Accumulating evidence supports roles for P2X4R in the central nervous system, including regulating cell excitability, synaptic transmission, and neuropathic pain. However, little information is available about the distribution and function of P2X4R in the peripheral nervous system. In this study, we find that P2X4R is mainly localized in the lysosomes of Schwann cells in the peripheral nervous system. In cultured Schwann cells, TNF‐a not only enhances the synthesis of P2X4R protein but also promotes P2X4R trafficking to the surface of Schwann cells. TNF‐a‐induced BDNF secretion in Schwann cells is P2X4R dependent. in vivo experiments reveal that expression of P2X4R in Schwann cells of injured nerves is strikingly upregulated following nerve crush injury. Moreover, overexpression of P2X4R in Schwann cells by genetic manipulation promotes motor and sensory functional recovery and accelerates nerve remyelination via BDNF release following nerve injury. Our results suggest that enhancement of P2X4R expression in Schwann cells after nerve injury may be an effective approach to facilitate the regrowth and remyelination of injured nerves.

Three‐dimensional velocity images of the crust and upper mantle beneath western China are obtained through seismic tomography by using P wave arrival times of local/regional and teleseismic events recorded in Chinese and Kyrgyzstan seismic networks. At shallow depths, most mountain belts and tectonically elevated areas are imaged as higher velocities, relative to adjacent sediment‐filled basins and foreland depressions with lower velocities. At mid‐lower crust depths, the Kyrgyz Tian Shan is underlain by lower velocity material and a distinct low‐velocity zone in the south‐north direction is observed between the eastern and western parts of the Chinese Tian Shan. The Moho of the southern Tarim basin has a greater depth over 50 km in front of the western Kun Lun, compared to the northern and western Tarim basin. Lateral heterogeneity within the upper mantle is apparent at depths from 71 to 571 km. The uppermost mantle beneath the Kyrgyz Tian Shan, Altay, Qi Lian, and eastern Kun Lun is characterized by low‐velocity material that is probably related to the upwelling of hot mantle. The lithospheric thickness varies from 120 to 170 km beneath the Chinese Tian Shan and northern Tibetan Plateau to 200–250 km beneath the Tarim basin. Deep coupling pattern of the Chinese Tian Shan with adjacent provinces can be classified into the embedding, detaching and sinking, and underthrusting of lithospheric roots. In addition, the lithosphere of the northern edge of the Tibetan Plateau seems to be thickened, in contrast to the central part of the northern plateau. North dipping low velocities exist in the upper mantle between the Tibetan Plateau and provinces to its north, which might indicate mantle flow from the Tibetan Plateau toward surrounding areas, but it has been blocked by the thick Tarim lithosphere.