To reduce the complexity and multiple constraints of logistics distribution routing problems, the author proposes an improved genetic algorithm, adaptive immune genetic algorithm (AIGA). The algorithm utilizes a new immune vaccine selection strategy and immune operation method, the optimization process is adaptively changed with the evolutionary algebra, combined with the parallel selection method to optimize the multiobjective logistics distribution path, and the specific steps to solve the multiobjective logistics distribution path problem are given. The experimental results show that the optimal path is calculated as 0—2—8—5—3—1—0; 0—4—7—6—0. AIGA not only efficiently converges to the optimal solution but also stabilizes to a fitness value of 66.5, reflecting better precision than IGA. The computational efficiency and convergence of the algorithm are significantly improved, which verifies the practicability and effectiveness of the algorithm. The adaptive immune genetic algorithm realizes the path optimization of complex logistics distribution, which can better change the global search performance of the original immune genetic algorithm, greatly improve the algorithm convergence speed, and achieve good results in practical applications.