Herein, we report a chiral bifunctional thiourea catalyzed asymmetric Michael addition reaction between 2-(trifluoromethyl)oxazol-5(2H)-one as a direct C-2-position nucleophile to 4-nitro-5-styrylisoxazoles for the first time.

Herein, the first copper(I)-catalyzed asymmetric 1,3-dipolar [3+2] cycloaddition of N-ester acylhydrazones and β-trifluoromethyl-α,β-unsaturated ketones has been developed, affording an array of chiral pyrazolidine derivatives containing a trifluoromethyl moiety bearing vicinal...

The formation of acyclic azomethine imine 1,3-dipoles via an N,N′-prototropic shift of hydrazones in the presence of Lewis acids, Brønsted acids and hydrogen-bonding catalysts is a fundamental and powerful strategy...