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This qualitative study investigated Chinese secondary teachers' perceptions and experiences of remote teaching immediately following the pandemic. Forty-two secondary teachers participated in the study. Data included 30-hour interviews and were analyzed using inductive methods to identify emerging codes and themes. Findings showed a wide variability in teachers' experiences with online teaching ranging from the workload change, parental involvement, and availability of technology resources. However, teachers developed a negative attitude toward remote learning while feeling underprepared to teach online. In addition, greater access to technology use during online teaching did not change Chinese teachers' views towards the goal of education and their overall teaching philosophy and pedagogy. The study provided practical implications regarding how to prepare effective classroom teachers using technology and improves distant education development and management.

Polymeric micelles are very attractive drug delivery systems for hydrophobic agents, owing to their readily tailorable chemical structure and ease for scale-up preparation. However, the intrinsic poor stability of drug-loaded micelles presents one of the major challenges for most micellar systems in the translation to clinical applications. In this study, a simple, well-defined, and easy-to-scale up 9-Fluorenylmethoxycarbonyl (Fmoc) and tert-butoxycarbonyl (Boc) containing lysine dendronized mPEG-PLA (mPEG-PLA-Lys(FB)) micellar formulation was designed and prepared for docetaxel (DTX) delivery, in an effort to improve the stability of the micelles, and its physicochemical properties, pharmacokinetics, and anti-tumor efficacy against SKOV-3 ovarian cancer were evaluated. MPEG-PLA-Lys(FB) was synthesized via a three-step synthetic route, and it actively interacted with DTX in aqueous media to form stable micelles with small particle sizes (~17-19 nm) and narrow size distribution (PI < 0.1), which can be lyophilized and easily reconstituted in saline without significant change in particle size distribution. In vitro drug-release study demonstrated that mPEG-PLA-Lys(FB) micelles achieved delayed and sustained release manner of DTX in comparison with mPEG-PLA micelles. Further in vivo xenograft tumor model in nude mice DTX/mPEG-PLA-Lys(FB) micelles demonstrated significantly higher inhibitory effect on tumor growth than the marketed formulation Taxotere. Thus, our system may hold promise as a simple and effective delivery system for DTX with a potential for translation into clinical study.