Soft tissue injuries (STIs) affect patients of all age groups and represent a common worldwide clinical problem, resulting from conditions including trauma, infection, cancer and burns. Within the spectrum of STIs a mixture of tissues can be injured, ranging from skin to underlying nerves, blood vessels, tendons and cartilaginous tissues. However, significant limitations affect current treatment options and clinical demand for soft tissue and cartilage regenerative therapies continues to rise.Improving the regeneration of soft tissues has therefore become a key area of focus within tissue engineering. As an emerging technology, 3D bioprinting can be used to build complex soft tissue constructs "from the bottom up," by depositing cells, growth factors, extracellular matrices and other biomaterials in a layer-by-layer fashion. In this way, regeneration of cartilage, skin, vasculature, nerves, tendons and other bodily tissues can be performed in a patient specific manner. This review will focus on recent use of 3D bioprinting and other biofabrication strategies in soft tissue repair and regeneration. Biofabrication of a variety of soft tissue types will be reviewed following an overview of available cell sources, bioinks and bioprinting techniques.

The present study examines if Facebooking can contribute to psychological well-being and if so, which aspects of Facebook use could play a significant role. Matching crawled data with self-reported datamotivation, and social network services (SNSs), such as Facebook, seem to provide a handy way to satisfy this basic human need. Then, is this social networking related to gratifying social relationships and psychological well-being? We attempted to answer this question by examining how Facebook users actually interact with their Facebook friends. Specifically, we focused on the number of Facebook interactions Facebook users has with their friends and the speed of friends' feedback to a Facebook user's post. We propose that more social interactions and faster responses from friends could be key aspects of understanding positive role of Facebook use in psychological well-being. We also investigate whether individual differences in sensitivity to other's behaviors and feelings (i.e., interpersonal awareness tendency) play a moderating role in the proposed relationships.To accomplish the aforementioned goals, we use two sets of data: crawled and self-reported data. First, we crawled study participants' one-month period of Facebook activities. As an unobtrusive and objective measure, crawled data could provide the reports about the number of Facebook interactions (e.g., number of comments to their posts) and each of their time stamps during the month prior to the study. Second, we conducted an online survey to measure participants' perceived social support and loneliness. Matching the two data sets allowed us to examine the relationship between Facebook use and psychological well-being.

Strong and tough synthetic hydrogels have received ever-increasing interests due to their potential applications as load-bearing structural materials. However, strong, tough, and recyclable hydrogels in different forms that can be generated by different methods according to various practical applications still remain an intrinsic bottleneck. A simple one-pot synthesis of multiurea linkage segmented linear copolymers with easy recyclability, hybridization, and processability, including compression molding, solution casting, and spinning methods, to yield ultrastrong and tough hydrogel films or stretchable hydrogel fibers with diameters ranged from macro-, micro-, to nanoscale, is reported here.

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Background Cervical cancer as one of the most common malignant tumors lead to bad prognosis among women. Some researches already focus on the carcinogenesis and pathogenesis of cervical cancer, but it is still necessary to identify more key genes and pathways. Methods Differentially expressed genes were identified by GEO2R from the gene expression omnibus (GEO) website, then gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyzed by DAVID. Meanwhile, protein–protein interaction network was constructed by STRING, and both key genes and modules were found in visualizing network through Cytoscape. Besides, GEPIA did the differential expression of key genes and survival analysis. Finally, the expression of genes related to prognosis was further explored by UNLCAN, oncomine, and the human protein atlas. Results Totally 57 differentially expressed genes were founded, not only enriched in G1/S transition of mitotic cell cycle, mitotic nuclear division, and cell division but also participated in cytokine–cytokine receptor interaction, toll‐like receptor signaling pathway, and amoebiasis. Additionally, 12 hub genes and 3 key modules were screened in the Cytoscape visualization network. Further survival analysis showed that TYMS (OMIM accession number ), MCM2 (OMIM accession number ), HELLS (OMIM accession number ), TOP2A (OMIM accession number ), and CXCL8 (OMIM accession number ) were associated with the prognosis of cervical cancer. Conclusion This study aim to better understand the characteristics of some genes and signaling pathways about cervical cancer by bioinformatics, and could provide further research ideas to find new mechanism, more prognostic factors, and potential therapeutic targets for cervical cancer.