Standard sequential therapy and 7-day levofloxacin triple therapy produced unacceptably therapeutic efficacy in China. Only levofloxacin-containing sequential therapy achieved borderline acceptable result. None of the regimens tested reliably achieved 90% or greater therapeutic efficacy in China.

The IL17F (rs763780, 7488T/C) variant was associated with an increased risk for the development of CD, and affected some clinical features of UC and CD. The IL17A (rs2275913, G-197A) variant had a weak association with the severity of UC. There was a risk haplotype in IL17A which could increase the risk of UC.

BackgroundPrevious studies implicated that IL23R and IL17 genes play an important role in autoimmune inflammation. Genome-wide association studies have also identified multiple single nucleotide polymorphisms (SNPs) in the IL23R gene region associated with inflammatory bowel diseases. This study examined the association of IL23R and IL17A gene SNPs with ulcerative colitis susceptibility in a population in China.MethodologyA total of 270 ulcerative colitis and 268 healthy controls were recruited for the analyses of 23 SNPs in the IL23R and IL17A regions. Genomic DNA was extracted and analysis of these 23 SNPs using ligase detection reaction allelic (LDR) technology. Genotype and allele associations were calculated using SPSS 13.0 software package.Principal FindingsCompared to the healthy controls, the variant alleles IL23R rs7530511, and rs11805303 showed a statistically significant difference for ulcerative colitis susceptibility (0.7% vs 3.3%, P = 0.002; 60.4% vs 53.2%, P = 0.0017, respectively). The linkage disequilibrium (LD) patterns of these SNPs were measured and three LD blocks from the SNPs of IL23R and one block from those of IL17A were identified. A novel association with ulcerative colitis susceptibility occurred in haplotypes of IL23R (Block1 H3 P = 0.02; Block2 H2 P = 0.019; Block3 H4 P = 0.029) and IL17A (H4 P = 0.034). Pair-wise analyses showed an interaction between the risk haplotypes in IL23R and IL17A (P = 0.014).ConclusionsOur study demonstrated that rs7530511, and rs11805303 of IL23R were significantly associated with ulcerative colitis susceptibility in the Chinese population. The most noticeable finding was the linkage of IL23R and IL17A gene region to ulcerative colitis risk due to the gene-gene interaction.

Background Gastric cancer (GC) is a highly malignant disease for which the development of novel biomarkers and therapeutic targets is urgently required. Decreased expression of Osteoglycin (OGN) has been observed in the progression of a variety of human cancers; however, the pathologic significance of OGN in GC remains unexplored. We aimed to detect the expression of OGN in gastric cancer tissues, and to evaluated the relationship between OGN expression and the clinico-pathological features in GC patients. Methods In this study, the expression levels of OGN were detected by immunohistochemistry (IHC) with the cohort including 44 gastric cancer samples and 40 non-tumorous samples. The data was statistically analyzed using GraphPad Prism 8.0. Results We found that OGN expression was downregulated in GC tissues compared to non-tumor counterparts. Furthermore, GC samples with lower OGN levels demonstrated higher lymph node metastasis. Histological analysis further confirmed that OGN downregulation was related to lower differentiation status of GC. Conclusions Collectively, our results indicate that dysregulation of OGN might be involved in GC development and that the expression of OGN may serve as a potential biomarker for monitoring of the progression of GC.