Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population

Zhang, Xiaofei; Yu, Pengli; Wang, Ying; Jiang, Wenyu; Shen, Fangcheng; Wang, Yamin; Tu, Huiming; Yang, Xiaozhong; Shi, Ruihua; Zhang, Hongjie

doi:10.1007/s00011-013-0629-9

Cited by 50 publications

(35 citation statements)

References 35 publications

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“…We also did not find any relationships between the IL-17A G197A polymorphism and susceptibility of RA. On the other hand, having A allele at the IL-17A G197A polymorphism site was found to be a protective factor in patients with ulcerative colitis (Zhang et al, 2013), whereas it was related with higher severity of mucosal inflammation in patients with gastric cancer (Shibata et al, 2009). Inconsistent with these results, we found possible relationships with DAS28 scores, VAS pain, and IL-17A G197A, but these associations did not reach a significant level.…”

Section: Discussionsupporting

confidence: 41%

The Influence of Polymorphisms of Interleukin-17A and -17F Genes on Susceptibility and Activity of Rheumatoid Arthritis

Görükmez

Dündar

et al. 2015

Genetic Testing and Molecular Biomarkers

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Section: Discussionsupporting

confidence: 41%

The Influence of Polymorphisms of Interleukin-17A and -17F Genes on Susceptibility and Activity of Rheumatoid Arthritis

Görükmez

Dündar

et al. 2015

Genetic Testing and Molecular Biomarkers

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“…Multiple previous studies have reported an association between IL-17 gene polymorphisms and autoimmune diseases (Jin et al, 2011;Zhang et al, 2013;Maalmi et al, 2014;Shen et al, 2015). Jin et al (2011) reported an association between IL-17 gene polymorphisms and susceptibility to asthma in a Korean population, and suggested that the rs1889570 polymorphism was correlated with the development of asthma.…”

Section: Discussionmentioning

confidence: 96%

“…Maalmi et al (2014) conducted a study in a Tunisian population, and found that the IL-17A rs2275913 and IL-17F rs763780 were associated with an increased risk of asthma in children. Zhang et al (2013) examined the association between IL-17 gene polymorphisms and inflammatory bowel disease, and reported that the IL-17 rs2275913 and rs763780 polymorphisms were associated with an increased risk of inflammatory bowel disease.…”

Section: Discussionmentioning

confidence: 99%

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Shi¹,

Zhang²

2015

Genet. Mol. Res.

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ABSTRACT. We conducted a case-control study in a Chinese population to examine the correlations between interleukin (IL)-17 gene polymorphisms and tuberculosis (TB) development. The study population included 336 TB subjects and 351 control subjects who were enrolled between June 2012 and June 2014. Genotyping analyses of IL-17A rs2275913 and rs3748067 and IL-17F rs763780 were analyzed using polymerase chain reaction-restriction fragment length of polymorphism. The genotype distributions of IL-17 rs2275913 were found to be in Hardy-Weinberg equilibrium in the controls, while the IL-17 rs3748067 and rs763780 were not. Based on unconditional logistic regression, individuals carrying the AA genotype and GA + AA genotype of rs2275913 were more likely to have a significantly increased risk of TB compared to subjects with the GG genotype. The ORs (95%CI) for the AA genotype and GA + AA genotype were 2.20 (1.35-3.60) and 1.52 (1.11-2.09), respectively. The CC genotype and TC + CC genotype of rs763780 were associated with increased risk of TB when compared with the TT genotype. The ORs (95%CI) for the CC genotype and TC + CC genotype were 1.99 (1.05-3.87) and 1.58 (1.07-2.33), respectively. In conclusion, rs763780 may play a critical role in the etiology of TB.

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“…IL-17A rs2275913 and IL-17F rs763780 are two common SNP loci in the IL-17 genes, and these two SNPs could influence the transcriptional regulation of IL-17. Previous studies have reported an association between IL-17A rs2275913 and IL-17F rs763780 and various diseases, such as inflammatory bowel disease, osteoarthritis, tuberculosis, and cancers (Zhang et al, 2013;Han et al, 2014;Bulat-Kardum et al, 2015;Gao et al, 2015). However, only two previous studies have reported an association between the IL-17A gene polymorphism and cardiovascular disease (Pei et al, 2009;Zhang et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Correlation between polymorphisms in the IL-17A and IL-17F genes and development of coronary artery disease

Geng¹,

Liu²,

Zhao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT.A case-control study was conducted to investigate the association between genetic variants of IL-17A rs2275913 and IL-17F rs763780 and the development of coronary artery disease (CAD) in a Chinese population. A total of 306 individuals with CAD and 306 unaffected individuals were enrolled from the Zhengzhou People's Hospital between May 2012 and May 2014. The IL-17A rs2275913 and IL-17F rs763780 genes were genotyped by polymerase chain reaction combined with a restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis revealed that individuals with the AA genotype of rs2275913 were associated with increased risk of CAD, compared to those with the GG genotype in a codominant model [adjusted odds ratio (OR) = 1.96; 95% confidence interval (CI) = 1.10-3.53]. On the other hand, the AA genotype of rs2275913 was correlated with moderately increased risk of CAD compared to the GG + GA genotype (adjusted OR = 1.76; 95%CI = 1.02-3.07) in a recessive model. However, no significant differences were observed between polymorphisms at the IL-17F rs763780 locus and CAD risk, in codominant, dominant, and recessive models. In conclusion, the results of our study suggested that the IL-17A rs2275913 polymorphism may affect the development of CAD; however, no significant association was observed between the IL-17F rs763780 polymorphism and risk of CAD.

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Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population

Cited by 50 publications

References 35 publications

The Influence of Polymorphisms of Interleukin-17A and -17F Genes on Susceptibility and Activity of Rheumatoid Arthritis

The Influence of Polymorphisms of Interleukin-17A and -17F Genes on Susceptibility and Activity of Rheumatoid Arthritis

Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Correlation between polymorphisms in the IL-17A and IL-17F genes and development of coronary artery disease

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