Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Shi, Guangcan; Zhang, L.-G.

doi:10.4238/2015.july.28.22

Cited by 26 publications

(41 citation statements)

References 18 publications

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“…A possible cause of the discrepancies between those previous results and our present data might be related to ethnic differences. Nevertheless, another study in China demonstrated a relationship between the G allele and the GG genotype with resistance to tuberculosis disease13. However, the TB population studied did not show HW equilibrium.…”

Section: Discussionmentioning

confidence: 80%

“…In order to find an association with resistance/susceptibility to tuberculosis, several studies investigated the rs2275913 SNP in ethnically different populations910134142. In a Croatian41 and a Chinese42 populations, no association between the SNP and tuberculosis were detected.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that allelic variants of the rs2275913 SNP differentially bind the transcription factor NFAT, leading to differences in IL-17A secretion30. Three previous reports demonstrated an association between the rs2275913 SNP and tuberculosis in populations from Spain, Brazil and China91013. Therefore, the aim of this study was to investigate the potential association of the IL-17A rs2275913 SNP and tuberculosis in Argentina.…”

mentioning

confidence: 96%

“…Particularly in tuberculosis, several SNPs have been reported as possible causes of disease resistance/susceptibility. Among them, there were described variations in cytokine genes such as IFN-γ, TNF-α, IL-1, IL-6, IL-10, IL-12 and IL-178910111213. However, only one study in the Argentinean population has reported the association between an IL-12 SNP and tuberculosis14.…”

mentioning

confidence: 99%

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The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina

Rolandelli

Pino

Pellegrini

et al. 2017

Sci Rep

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Mycobacterium tuberculosis (Mtb) causes nearly 10 millions of new tuberculosis disease cases annually. However, most individuals exposed to Mtb do not develop tuberculosis, suggesting the influence of a human genetic component. Here, we investigated the association of the rs2275913 SNP (G → A) from IL-17A and tuberculosis in Argentina by a case-control study. Furthermore, we evaluated in vitro the functional relevance of this SNP during the immune response of the host against Mtb and analyzed its impact on clinical parameters of the disease. We found an association between the AA genotype and tuberculosis resistance. Additionally, within the healthy donors population, AA cells stimulated with a Mtb lysate (Mtb-Ag) produced the highest amounts of IL-17A and IFN-γ, which further support the genetic evidence found. In contrast, within the tuberculosis patients population, AA Mtb-Ag stimulated cells showed the lowest immunological parameters and we evidenced an association between the AA genotype and clinical parameters of disease severity, such as severe radiological lesions and higher bacilli burden in sputum. Overall, our findings demonstrated that the AA genotype from the IL-17A rs2275913 SNP is positively associated with protection to active tuberculosis but related to higher disease severity in the Argentinean population.

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 96%

mentioning

confidence: 99%

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The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina

Rolandelli

Pino

Pellegrini

et al. 2017

Sci Rep

View full text Add to dashboard Cite

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“…Milano et al demonstrated that the A allele of IL17A (rs2275913) occurred more frequently in a control group than in patients with pulmonary tuberculosis and suggested that A or G allele in this position are associated with susceptibility to TB . Shi and Zhang concluded that the AA and GA + AA genotypes of rs2275913 are associated with increased risk of pulmonary tuberculosis . Ocejo‐Ocejo‐Vinyals et al demonstrated a correlation between IL‐17A rs2275913–152G allele and GG genotype and pulmonary tuberculosis and that (1s434666) serum IL‐17 titers were higher in patients than in controls .…”

Section: Discussionmentioning

confidence: 99%

Association of interleukin‐17 gene polymorphisms and susceptibility to brucellosis in Hamadan, western Iran

Keramat

Kazemi

Saidijam

et al. 2019

Microbiology and Immunology

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IL‐17is one of the most important inflammatory cytokines that stimulate immunity responses in humans infected with Brucella species, acting as a regulator that reduces release of γ‐IFN, thus increasing resistance to brucellosis. Gene polymorphisms in the regulatory regions of cytokine‐encoding genes affect the amountsof cytokines produced and play a fundamental role in infectious diseases. The aim of this study was to determine the association between IL‐17 gene polymorphisms and susceptibility to brucellosis. In this case‐control study, 86 patients with brucellosis and 86 healthy persons in Hamadan, western Iran, from September 2014 to September 2016, were included. IL‐17 genetic variants at positions rs4711998 A/G, rs8193036 C/T, rs3819024 A/G, rs2275913 A/G, rs3819025 A/G, rs8193038 A/G, rs3804513 A/T, rs1974226 A/G and rs3748067 A/G were analyzed by restriction fragment length polymorphism‐PCR. Serum IL‐17 titers were measured by sandwich ELISA. GG genotypes at positions rs4711998 and rs3748067 were present significantly more frequently in patients with brucellosis than in controls (P < 0.05). The AA genotype at positions rs4711998, rs2275913 and rs3748067 and GG genotype at position rs19744226 were present significantly more frequently in controls than in the patient group. These results suggest that the AA genotype at positions rs3748067, rs3819025 and rs4711998 and GG genotype at position rs3819024 are likely protective factors against brucellosis, whereas the GG genotype at positions rs3748067, rs3819025 and rs4711998 and AA genotype at position rs3819024 may be risk factors against the disease. No significant relationships were found between serum IL‐17 titers and genotypes of the single‐nucleotide polymorphisms.

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Seasonal influenza A/H3N2 virus infection and IL‐1Β, IL‐10, IL‐17, and IL‐28 polymorphisms in Iranian population

Rogo

Rezaei

Marashi

et al. 2016

Journal of Medical Virology

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Increased blood cytokines is the main immunopathological process that were attributed to severe clinical outcomes in cases of influenza A/H3N2 virus infection. The study was aimed to investigate the polymorphisms of IL-1β, IL-10, IL-17, and IL-28 genes to find the possibility of their association with the clinical outcome of influenza A/H3N2 virus infection among the infected patients in Iran. This is a Case-Control study in which influenza A/H3N2 virus positive confirmed with real-time PCR were the cases. DNA samples from groups were genotyped for polymorphisms in rs16944 (IL-1β), rs1800872 (IL-10), rs2275913 (IL-17), and rs8099917 (IL-28). Confidence interval (95%CI) and Odds ratio (OR) were calculated. IL-17 rs2275913 (GG and AG) were associated with risk of infection with that were statistically significant (P < 0.05, OR = 2.08-2.94). IL-1β (rs16944) (GG) was associated with reduced risk of infection (P < 0.01, OR = 0.46). Genotype GG and GT of IL-10 (rs1800872) were associated with increased risk of infection with influenza A/H3N2 virus (P < 0.05, OR = 2.04-2.58). In addition, IL-28 (rs8099917) genotypes GG (P < 0.05, OR = 0.49) and TG (P < 0.05, OR = 0.59) were associated with reduced risk of ILI symptom while genotype TT (P < 0.01, OR = 4.31) was associated with increased risk of ILI symptom. The results of this study demonstrated that polymorphisms of genes involved in the inflammatory and anti-inflammatory process affect the outcome of disease caused by influenza A/H3N2 virus. Thorough insight on host immune response at the time of influenza A virus infection is required to ensure adequate patient care in the case of feature outbreaks. J. Med. Virol. 88:2078-2084, 2016. © 2016 Wiley Periodicals, Inc.

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Influence of interleukin-17 gene polymorphisms on the development of pulmonary tuberculosis

Cited by 26 publications

References 18 publications

The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina

The IL-17A rs2275913 single nucleotide polymorphism is associated with protection to tuberculosis but related to higher disease severity in Argentina

Association of interleukin‐17 gene polymorphisms and susceptibility to brucellosis in Hamadan, western Iran

Seasonal influenza A/H3N2 virus infection and IL‐1Β, IL‐10, IL‐17, and IL‐28 polymorphisms in Iranian population

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