The widely used antibiotic metronidazole (MTZ) was investigated for its toxic effects on the liver of the common carp (Cyprinus carpio L.). The fish were exposed to 0.1, 0.5, and 2.5 mg/L MTZ in water for 30 days, and parameters that are indicative of liver damage and oxidative stress were measured. MTZ increased liver ethoxyresorufin-O-deethylase, malondialdehyde, and glutathione levels, and elevated the activities of superoxide dismutase, catalase, aspartate aminotransferase, and alanine aminotransferase. These parameters usually showed significant differences in the 0.5 and 2.5 mg/L MTZ groups compared to the control group (p < 0.05). These findings indicated that MTZ induced oxidative stress and caused liver damage in common carp, suggesting that measures should be taken to avoid contamination of surface waters with MTZ.

groups according to ABI. The correlation between cardiovascular risk factors, ABI and the CAD severity were analysed. Results Gensini score (69.0620.1), three vessel (56, 56%) and B 2 /C type stenotic lesion (79, 79%) was significantly higher in ABI<0.9 group compared with control group (50.7617.6), (19, 23.8%), (31, 38.8%). Result Gensini score (69.0620.1), three vessel (56, 56%) and B 2 /C type stenotic lesion (79, 79%) was significantly higher in ABI<0.9 group, Compared with control group (50.7617.6), (19, 23.8%), (31, 38.8%). Binary regression analysis showed that ABI, correlated with several risk factors, was a statistically significant independent predictor for three vessel or complex (B 2 /C) stenotic lesions and odds ratio were 3.620 and 4.011 respectively. The stepwise multivariable regression analysis shown, ABI<0.9 (R¼À3.018, P<0.05) and age (R¼1.206, P<0.05) enter the gensini score regression equation. Conclusion ABI is negatively correlated with the degree of coronary artery stenosis. ABI#0.9 is a good predictor of severe coronary artery disease. Objective Homozygous familial hypercholesterolaemia (HoFH) is a rare disorder characterised by the early onset of atherosclerosis and usually occurrs at the ostia of coronary arteries. In this study we used transthoracic Doppler echocardiography (TTDE) to evaluate the dynamic changes of coronary flow in HoFH patients and to detect aortic and coronary atherosclerosis by dual-source CT (DSCT). Method 20 HoFH patients (12 females, 8 males, mean age 13.165.3 years, with a mean low density lipoprotein (LDL) cholesterol 5836113 mg/dl) was studied as experimental group and fifteen patients (8 females, 7 males, mean age 15.266.9 years, with a mean low density lipoprotein (LDL) cholesterol 128671 mg/dl) as control group by TTDE and DSCT. Result None of the patients showed evidence of ischaemia with standard exercise testing. Though the baseline coronary flow was similar between HoFH patients and normal controls, the hyperaemic flow velocities and thus the coronary flow velocity reserve (CFVR) were significantly lower in those with HoFH (3.36 vs 1.92 respectively, p<0.0001). All HoFH patients had aortic plaques, amongst which nine of them occurred at the coronary artery ostia, who had significantly higher LDL-cholesterol and lower CFVR than those without ostia plaques. Conclusion Our data demonstrated that TTDE together with DSCT could be a useful non-invasive method for detection of coronary flow dynamics and atherosclerosis specifically in HoFH subjects with coronary ostia involved. Introduction Sinus of Valsalva aneurysms (SVA) are rare cardiac anomalies. They may be congenital or acquired and are usually asymptomatic unless complicated by such developments as intracardiac rupture with formation of a fistula or aortic valvular insufficiency. The following case is unusual in that the presenting symptom was angina pectoris due to severe atherosclerotic coronary disease with development of an aneurysm of the sinus of Valsalva secondary to atherosclerotic involvement...

Objective:To analyze the correlation between coronary artery lesion and cardiac function change among elderly patients with coronary heart disease (CHD).Methods:A total of 171 elderly patients with CHD hospitalized from 2009 to 2016 were selected. Their ultrasonic cardiographic and coronary angiographic data were collected, and the correlation between coronary artery lesion and left ventricular remodeling, systolic and diastolic function was analyzed.Results:Coronary artery lesion among elderly patients with CHD was closely related with left ventricular remodeling and systolic function change, but not significantly correlated with diastolic function change.Conclusion:Coronary artery lesion severity of elderly patients with CHD was an important reason for left ventricular remodeling and cardiac systolic function change. Early intervention of coronary artery disease is of great significance to protect the heart function.