The device presented could give convincing results. The in vivo mechanical properties of human facial skin obtained by our modified formula agree well with open literature, and a better reliability than classical Hertz theory is evidenced.

In recent years, the incidence of cancer is high around the world, and the resistance of bacteria is increasing. To cope with the potentially adverse side effects of cancer chemotherapy and surgery, researchers are turning to the construction of new drug scaffolds. The indoline structure exists in a huge number of natural products, but drugs with indoline have only been formally studied in recent years. With the deepening of research, drugs containing indoline have played important roles in more disease treatment aspects, such as anti‐tumor, anti‐bacterial, anti‐inflammatory and have been used as analgesics, to treat cardiovascular diseases and so on. The synthesis and pharmacological activity of indoline derivatives is summarized in this review in order to support the addition of the indoline component to the toolbox of medicinal chemists. This review focuses on the advantages of indoline compounds in development and synthesis of and for the use as anticancer drugs, antibacterial drugs, to treat cardiovascular diseases and as anti‐inflammatory and analgesic drugs. Indoline structures are commonly found in natural and synthetic compounds with medicinal value and are now beginning to be exploited as the basic backbone of various drugs. As research continues, dihydroindoles and their derivatives will play a greater role in the medical field.

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In vivo characterization of facial soft tissue is of great significance for facial plastic surgery, animation and dermatology. This paper presents an in vivo experimental method to characterize the macroscopic mechanical properties of facial soft tissue. In this method, a bi-layer material (BLM) model is established with the skeleton as the substrate under the facial soft tissue and the relationship between the mechanical properties of soft tissue and force–displacement curve is obtained. A novel indentation apparatus is also developed to experimentally measure the force-displacement curve of the facial soft tissue in vivo. Using the apparatus, experiments were conducted on artificial skins to verify the theoretical model. Experiments on facial soft tissue were finally conducted on four volunteers to obtain Young’s moduli at five facial locations using an optimal indenter whose radius is determined by the verification experiment. Our experiment results indicate that a slight difference is observed in Young’s moduli of facial soft tissue among different volunteers and indentation location. At locations of the left-hand cheek near the lips (NE) and center of the left-hand jaw (CJ), Young’s moduli [Formula: see text] are relatively large ranging from 2.653[Formula: see text]kPa to 4.437[Formula: see text]kPa. Nevertheless, at other locations of the center of the cheek (CC), left-hand zygomatic region (ZYG) and left-hand cheek near the lips (NL), the contact forces are smaller, and Young’s moduli [Formula: see text] are between 1.649[Formula: see text]kPa and 3.395[Formula: see text]kPa.

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