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Signal transducer and activator of transcription (STAT) family consist of seven members, STAT1, 2, 3, 4, 5α, 5β, 6 (Darnell, 1997). Among them, STAT1, STAT3, and STAT5 are highly associated with human tumorigenesis and development due to their frequent hyperactivation (Benekli et al., 2009). In normal cells, STAT3 responds to the stimulation of various extracellular signaling factors and then transmits them through phosphorylation of the tyrosine kinase site (Tyr705) in the SH2 domain. Once in the nucleus, STAT3 binds to DNA and subsequently activates transcription and translation, thus performing various physiological functions (Furtek et al., 2016;Ren et al., 2015;Yamamoto et al., 2002). However, according to previous research, STAT3 is involved in the process of growth, proliferation, angiogenesis, and invasion of tumor cells (Bromberg & Chen, 2001). Abnormally high expression