Monascus rice ferment extracts has anti-oxidant and antibiotic efficiency. Oxidative stress contributes to skin aging and can adversely affect skin health, which means antioxidants active in skin cells may support skin health. Antioxidant can contribute to defending old. Suppress the production that the epidermis bacterium can reduce the whelk and comedo. Our objective to evaluate the antioxidant properties, antibacterial activity and protective effects on UV-induced damage in HaCaT keratinocytes of extra different carbon and nitrogen sources at water (MRW) and methanolic (MRM) extracts from Monascus purpureus BCRC 31615 fermented rice. Effectiveness in reducing powers and DPPH radical scavenging ability was Monascus rice add MSG water extract has prominent ability. The ferment rice added nitrogen source to increase total phenols and kojic acid content. Antibacterial activities showed good in inhibition Staphylococcus aureus BCRC 10780. Protective effects on UV-induced damage in HaCaT keratinocytes which M. purpureus ferment rice added with extra nitrogen source was especially potent in inhibited UV-induced keratinocyte death.