With the approval of first 3D printed drug “spritam” by USFDA, 3D printing is gaining acceptance in healthcare, engineering and other aspects of life. Taking 3D printing towards the next step gives birth to what is referred to as “4D printing”. The full credit behind the unveiling of 4D printing technology in front of the world goes to Massachusetts Institute of Technology (MIT), who revealed “time” in this technology as the fourth dimension.  4D printing is a renovation of 3D printing wherein special materials (referred to as smart materials) are incorporated which change their morphology post printing in response to a stimulus. Depending upon the applicability of this technology, there may be a variety of stimuli, most common among them being pH, water, heat, wind and other forms of energy.  The upper hand of 4D printing over 3D printing is that 3D printed structures are generally immobile, rigid and inanimate whereas 4D printed structures are flexible, mobile and able to interact with the surrounding environment based on the stimulus. This capability of 4D printing to transform 3D structures into smart structures in response to various stimuli promises a great potential for biomedical and bioengineering applications. The potential of 4D printing in developing pre-programmed biomaterials that can undergo transformations lays new foundations for enabling smart pharmacology, personalized medicine, and smart drug delivery, all of which can help in combating diseases in a smarter way. Hence, the theme of this paper is about the potential of 4D printing in creating smart drug delivery, smart pharmacology, targeted drug delivery and better patient compliance. The paper highlights the recent advancements of 4D printing in healthcare sector and ways by which 4D printing is doing wonders in creating smart drug delivery and tailored medicine. The major constraints in the approach have also been highlighted. Keywords: 4D printing, smart, drug delivery system, patient compliance, biomaterials, tailored medicine

Background and Objective: Comparative efficacy of medical termination has always remained debatable as compared to surgical techniques. The study was designed to assess the safety, acceptability and success of oral Misoprostol as an agent of medical termination as compared to surgical evacuation in cases of early pregnancy loss.Methods: This was a quasi-experimental study conducted in Department of Obstetrics and Gynaecology at Sughra Shafi Medical Complex, affiliated with Sahara Medical College Narowal from August 2017 to February 2019. Diagnosed cases of missed miscarriage before 13 weeks (n = 150) were allocated either for surgical evacuation (n = 50) or medical termination by oral Misoprostol (n = 100) on patients' own choice after counselling. Effective dosage schedule of Misoprostol, its adverse effects, number of days taken for complete expulsion and duration of hospital stay were recorded. Main outcome measure was successful termination.Results: Patients enrolled for surgical evacuation had 100% success rate while those in medical termination had 80% success rate and 20% treatment failure.Significant differences were also observed in symptoms, bleeding and hospital stays between the two groups. Conclusion:Surgical evacuation is still a gold standard method recommended for suitable cases, while medical termination by Misoprostolis low cost, better accepted and effective but has unpredictable outcomes.