On May 10, 2021, Brazil ranked second in the world in COVID-19 deaths. Understanding risk factors, or social and ethnic inequality in health care according to a given city population and political or economic weakness is of paramount importance. Brazil had a seriousness COVID-19 outbreak in light of social and economic factors and its complex racial demographics. The objective of this study was to verify the odds of mortality of hospitalized patients during COVID-19 infection based on their economic, social, and epidemiological characteristics. We found that odds of death are greater among patients with comorbidities, neurological (1.99) and renal diseases (1.97), and immunodeficiency disorders (1.69). While the relative income (2.45) indicates that social factors have greater influence on mortality than the comorbidities studied. Patients living in the Northern macro-region of Brazil face greater chance of mortality compared to those in Central-South Brazil. We conclude that, during the studied period, the chances of mortality for COVID-19 in Brazil were more strongly influenced by socioeconomic poverty conditions than by natural comorbidities (neurological, renal, and immunodeficiency disorders), which were also very relevant. Regional factors are relevant in mortality rates given more individuals being vulnerable to poverty conditions.

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