No abstract

The SW South China Sea preserves a propagating oceanic spreading centre and associated continent-ocean transition (COT) that characterizes the continental margin offshore SE Vietnam. We investigated the nature of strain accommodation in the region immediately in front of the propagating rift using a combination of 1-and 2-D backstripping subsidence reconstructions, coupled with forward modelling based on the measured upper crustal extensional faulting applied to a flexural cantilever model. Major normal faulting ceases after an inversion event at ca. 16 Ma, although moderate extension was also noted at 22-23 Ma, representing the end of an extensional phase that initiated around 28 Ma. 1-D subsidence models indicate rapid 'syn-rift' subsidence, possibly lasting until 10 Ma, despite the lack of observed extensional faulting. We show that depth-dependent extension is required to explain the great depth of the basins despite the modest observed upper crustal faulting. Brittle faulting could not have extended much deeper than 10 km, suggestive of weak crust in the presence of high heatflow. The regional topographic slope on the basement suggests very low mid-crustal viscosities of 10 19 -10 20 Pa.s., consistent with the idea that flow in the ductile mid and lower crust was responsible for much of the subsidence prior to, and possibly after, seafloor spreading, which extended ca. 300 km from the tip of the mid ocean ridge. Flow is inferred to be dominant towards the spreading centre prior to 16 Ma. Extension in the COT postdates seafloor spreading and further supports the idea of this crust being very weak, albeit with more coherent, less extended crustal fragments, now forming banks offshore the Sunda continental shelf and surrounded by hyperextended crust of the COT.

Katherine West Health Board Aboriginal Corporation (KWHB) at Katherine in the Northern Territory is an Aboriginal health service delivery organization directed by the Indigenous Board. The Chronic Disease Self-Management Demonstration Project (CDSM) commenced in April, 2002 at KWHB with funding from the Commonwealth Department of Health and Ageing Sharing Health Care initiative, as one of eight demonstration projects across the country. The project is under the direction of the KWHB Board, which is made up of 18 members elected by their own communities that lie within the KWHB service sector. The full Board or the Board Executive meet routinely throughout each year and members are actively involved with the project at both community and Board levels. The project governance structure also includes a Steering Committee and the Project Management Group that meets monthly. The project is well supported by the various management and administrative sections of KWHB. In the communities, the project reports to the local health committees that have been established by KWHB with community support, and to the local CDSM committees made up of members of the target group.

Long-term memory T cells have not been well analyzed in individuals vaccinated with a COVID-19 vaccine although analysis of these T cells is necessary to evaluate vaccine efficacy. Here, investigate HLA-A*24:02-restricted CD8+ T cells specific for SARS-CoV-2-derived spike (S) epitopes in individuals immunized with the BNT162b2 mRNA vaccine. T cells specific for the S-QI9 and S-NF9 immunodominant epitopes have higher ability to recognize epitopes than other epitope-specific T cell populations. This higher recognition of S-QI9-specific T cells is due to the high stability of the S-QI9 peptide for HLA-A*24:02, whereas that of S-NF9-specific T cells results from the high affinity of T cell receptor. T cells specific for S-QI9 and S-NF9 are detectable >30 weeks after the second vaccination, indicating that the vaccine induces long-term memory T cells specific for these epitopes. Because the S-QI9 epitope is highly conserved among SARS-CoV-2 variants, S-QI9-specific T cells may help prevent infection with SARS-CoV-2 variants.

Background: Attempts to achieve digital transformation across the health service have stimulated increasingly large-scale and more complex change programmes. These encompass a growing range of functions in multiple locations across the system and may take place over extended timeframes. This calls for new approaches to evaluate these programmes. Main body: Drawing on over a decade of conducting formative and summative evaluations of health information technologies, we here build on previous work detailing evaluation challenges and ways to tackle these. Important considerations include changing organisational, economic, political, vendor and markets necessitating tracing of evolving networks, relationships, and processes; exploring mechanisms of spread; and studying selected settings in depth to understand local tensions and priorities. Conclusions: Decision-makers need to recognise that formative evaluations, if built on solid theoretical and methodological foundations, can help to mitigate risks and help to ensure that programmes have maximum chances of success.