Work-Life Balance began to develop in the twentieth century, especially in women who have difficulty balancing family responsibility and work duties. With the end of the 21st century, this problem is not limited to women but occurs to men and their partners, who work and have difficulty fulfilling both roles (family and work). One of the causes of disruption in fulfilling these roles is the existence of technology. Technology can make someone disturbed because when they are with their families they are still doing work mattres. It can cause conflict in the family or at work (work-family conflict) or it can also be caused by job stress (Job Stress). This research was conducted to determine the effect of work to family conflict and family to work conflict on work-life balance and job stress is used as a mediating factor affecting Work-Life Balance. This research also compares the effects that occur in men and women. By using 206 data of employees domiciled in JABODETABEK as the sample and applying a parsial least square-structural equation model (PLS-SEM) to analyze the data, this study tested five hypotheses. The results showed two important findings: [1] Work to family conflict can affect work-life balance even though job stress has no influence in mediating work-life balance. [2] Gender is not able to moderate the influence of Work to Family Conflict, Family to Work Conflict on Work-Life Balance through Job Stress. It implies that men and women have the same influence in achieving work-life balance.