Radio Frequency (RF) power amplifier (PA), power oscillator (PO), mixer, and their test circuit simulation results were presented for biomedical engineering applications. The novel efficient Class-E type RF PA was designed, and a schematic circuit was simulated. RF circuit blocks were designed and implemented at the 130 nanometers (nm) standard CMOS RF technology. Schematic test circuit simulations were tested with antenna connection which includes two-wire bonding inductances and antenna inner resistance. According to the circuit simulation results, no extra mismatch tuning circuit was needed between PA, PO, and mixer output and antenna input stages. For demonstration purposes, 33 GHz extremely high frequency (EHF) band PA input voltage was applied at 300 mV peak-to-peak (pp) voltage level. Technology standard 1V RF n-channel Metal-Oxide-Silicon (MOS) transistor was used as a Class-E type active transistor switch. For PA circuit simulation, test results show that the proposed circuit runs better than traditional Class-E type RF PAs. 70% power amplifier efficiency (PAE) for -8.5 dBm power input at 33 GHz RF input frequency for 40 harmonics and 15 steps in the harmonic shoot balance mode was achieved. The whole circuit blocks were designed and implemented for biomedical engineering which was specifically requested for the glucose detection system.