No abstract

Background: High-grade transformation or dedifferentiation in carcinoma is progression of a low-grade malignant neoplasm to a high-grade carcinoma or poorly differentiated adenocarcinoma. This is rarely observed in adenoid cystic carcinoma of the salivary glands.Case Report: A 39 year-old woman presented with a painless mass at the left submandibulary region that had been growing slowly for 5 years. Submandibulary mass resection revealed a mass with peripheral adenoid cystic carcinoma and a central high-grade tumor delineated with a fibrous rim, raising the possibility of a hybrid or composite carcinoma, requiring differential diagnosis depending upon morphology and immunohistochemistry findings. The final histopathological diagnosis was high-grade transformation of adenoid cystic carcinoma. After surgical therapy, the patient was irradiated to the neck and submandibulary region. No sign of tumor recurrence has been evident for 36 months.Conclusion: This present case seems to be another rare case with high-grade transformation of adenoid cystic carcinoma and the fibrous rim may be a histopathological feature of such cases, which should be kept in mind.

Warthin tumor is a well-defined benign salivary gland neoplasm consisting of both epithelial and lymphoid components. The tumor is the second most common benign tumor next to pleomorphic adenoma. We present a case of adenocarcinoma, not otherwise classified, arising in unilateral Warthin tumor of the parotid gland in a 63-year-old male patient. Carcinomas arising in or from the epithelial component of a preexisting parotid Warthin tumor are rare and differential diagnosis of metastasis from an adenocarcinoma in Warthin tumor is important. The patient underwent a complete and thorough work-up, and no other primary malignant lesion was found. No other primary malignant lesion had manifested at the last one year follow-up period.

Neck mass is a symptom that could be seen in all age groups and brings significant trouble. IN differential diagnosis of the neck masses wide spectrum of diseases should be considered. Therefore, our aim is to achieve a quick and accurate diagnosis and also not to harm patients. Neck mass may be due to a simple infection or a first sign of head and neck region tumor. Patients with neck masses must be evaluated with a detailed head and neck physical examination, further tests like fine needle aspiration biopsy may also be required. Excisional biopsy should be done if necessary. Most of the benign or malign lesions are the cause of masses on the neck. Key words: Neck mass,fine needle aspiration biopsy,malignancy. ÖZBoyunda kitle, her yaş grubunu etkileyebilen ve hastaları oldukça endişelendiren bir semptomdur. Boyun kitlelerinin ayırıcı tanısı çok geniş hastalıklar spektrumunun tanısı ve tedavisi konusunda detaylı bir bilgi sahibi olmayı gerektirir. Boyundaki kitle basit bir enfeksiyona bağlı olabileceği gibi baş boyun bölgesi kaynaklı bir tümörün ilk belirtisi olarak veya vücudun başka bölgesinde bulunan bir tümörün uzak metastazı şeklinde de karşımıza çıkabilir. Baş-boyun kitlesinde mutlaka ayrıntılı baş-boyun ve fizik muayene, ileri tetkikler ve ince iğne aspirasyon biopsisi yapılmalıdır. Gerektiği durumlarda eksizyonel biopsi uygulanmalıdır. Benign ya da malign özellikteki pek çok lezyon boyunda kitle sebebidir. Anahtar kelimeler: Boyunda kitle,ince iğne aspirasyon biopsisi,malign,benign.

No abstract