rare cases isolated sphenoid has been reported, which represent only 2.7% of all sinus diseases [3,4]. There are several important structures adjacent to sphenoid sinus which vulnerable to injury through any sphenoid sinus lesion, including the pituitary gland, optic nerve and chiasm, middle cranial fossa, internal carotid artery, cavernous sinus, the dura, pterygoid canal and nerve and cranial nerve III, IV, V1, V2, and VI [1,2]. Even though isolated sphenoid sinus lesion is rare, it's very significant clinically due to its undetectable anatomical location, ambiguous symptoms and the complications associated with injury to the above structures [5]. The main focus of this study is to present the different clinical