Background: Stroke has high rates of mortality and severe sequelae such as aphagia and paralysis. Nutrition labels provide important characteristics about food. This study aimed to examine the association between the influence of nutrition labels and the prevalence of stroke. Methods: This study examined original data of the National Health and Nutrition Examination Survey (2015)(2016)(2017)(2018)(2019). A multivariate logistic regression analysis was performed of the data of 18,129 adults over 40 years of age divided into four groups: no recognition of nutrition labels (NR), no use of nutrition labels (NU), no reflection but use of nutrition labels (NRU), and reflection of nutrition labels (R). The data were adjusted for age, household income, educational level, occupation, drinking, smoking, exercise habits, and other diseases and the prevalence of stroke was examined. Results: Patients who were female, younger, or highly educated or had a high household income were more likely influenced by nutrition labels since they were more likely to purchase food (P<0.001). The prevalence of stroke was higher among patients who were older, were male, and had a lower household income and lower education level (P<0.001). The prevalence of stroke was significantly lower among male in the R versus NR group (adjusted odds ratio [aOR] 0.388; 95% confidence interval [CI] 0.201-0.752) as well as among patients over 70 years of age (aOR 0.271; 95% CI 0.113-0.650). Conclusion:In this study, a significant association was confirmed between nutrition label use and the prevalence of stroke among men and older individuals.